Assay Detail
Binding
CHEMBL615840
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Compound was evaluated for its ability to displace [3H]8-OH-DPAT from serotonin 5-hydroxytryptamine 1A receptor in rat cerebral cortex membranes
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Tissue | Cerebral cortex |
| Subcellular | Membrane |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
2-[4-(o-methoxyphenyl)piperazin-1-ylmethyl]-1,3-dioxoperhydroimidazo[1,5-a]pyridine as a new selective 5-HT1A receptor ligand
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 8.14 | 8.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL27429 | — | — | 1 | 8.70 |
| CHEMBL13647 | BMY-7378 | — | 1 | 8.62 |
| CHEMBL440302 | — | — | 1 | 7.10 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL27429 | — | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL13647 | BMY-7378 | IC50 | = | 2.4 | nM | 8.62 |
| CHEMBL440302 | — | IC50 | = | 80.0 | nM | 7.10 |