Assay Detail
Binding
CHEMBL615844
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Binding affinity for 5-hydroxytryptamine 1A receptor in rat brain tissue using [3H]8-OH-DPAT as radioligand
23
Total Activities
23
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Tissue | Brain |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
Derivatives of cis-2-amino-8-hydroxy-1-methyltetralin: mixed 5-HT1A-receptor agonists and dopamine D2-receptor antagonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 23 | 7.31 | 9.25 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL290091 | — | — | 1 | 9.25 |
| CHEMBL41187 | — | — | 1 | 8.59 |
| CHEMBL43475 | — | — | 1 | 8.54 |
| CHEMBL26998 | — | — | 1 | 8.39 |
| CHEMBL290446 | — | — | 1 | 8.22 |
| CHEMBL290546 | — | — | 1 | 8.17 |
| CHEMBL289106 | — | — | 1 | 8.12 |
| CHEMBL40634 | — | — | 1 | 7.75 |
| CHEMBL288284 | — | — | 1 | 7.42 |
| CHEMBL297143 | — | — | 1 | 7.36 |
| CHEMBL41802 | — | — | 1 | 7.31 |
| CHEMBL288721 | — | — | 1 | 7.09 |
| CHEMBL38192 | — | — | 1 | 6.94 |
| CHEMBL38748 | — | — | 1 | 6.86 |
| CHEMBL288540 | — | — | 1 | 6.63 |
| CHEMBL287770 | — | — | 1 | 6.54 |
| CHEMBL40603 | — | — | 1 | 6.38 |
| CHEMBL38916 | — | — | 1 | 5.85 |
| CHEMBL40264 | — | — | 1 | 5.54 |
| CHEMBL288583 | — | — | 1 | 5.18 |
| CHEMBL44569 | — | — | 1 | - |
| CHEMBL41801 | — | — | 1 | - |
| CHEMBL41261 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL290091 | — | Ki | = | 0.56 | nM | 9.25 |
| CHEMBL41187 | — | Ki | = | 2.6 | nM | 8.59 |
| CHEMBL43475 | — | Ki | = | 2.9 | nM | 8.54 |
| CHEMBL26998 | — | Ki | = | 4.1 | nM | 8.39 |
| CHEMBL290446 | — | Ki | = | 6.0 | nM | 8.22 |
| CHEMBL290546 | — | Ki | = | 6.7 | nM | 8.17 |
| CHEMBL289106 | — | Ki | = | 7.6 | nM | 8.12 |
| CHEMBL40634 | — | Ki | = | 18.0 | nM | 7.75 |
| CHEMBL288284 | — | Ki | = | 38.0 | nM | 7.42 |
| CHEMBL297143 | — | Ki | = | 44.0 | nM | 7.36 |
| CHEMBL41802 | — | Ki | = | 49.0 | nM | 7.31 |
| CHEMBL288721 | — | Ki | = | 81.0 | nM | 7.09 |
| CHEMBL38192 | — | Ki | = | 116.0 | nM | 6.94 |
| CHEMBL38748 | — | Ki | = | 138.0 | nM | 6.86 |
| CHEMBL288540 | — | Ki | = | 236.0 | nM | 6.63 |
| CHEMBL287770 | — | Ki | = | 285.0 | nM | 6.54 |
| CHEMBL40603 | — | Ki | = | 417.0 | nM | 6.38 |
| CHEMBL38916 | — | Ki | = | 1420.0 | nM | 5.85 |
| CHEMBL40264 | — | Ki | = | 2920.0 | nM | 5.54 |
| CHEMBL288583 | — | Ki | = | 6650.0 | nM | 5.18 |
| CHEMBL44569 | — | Ki | > | 1000.0 | nM | - |
| CHEMBL41801 | — | Ki | > | 1000.0 | nM | - |
| CHEMBL41261 | — | Ki | > | 1000.0 | nM | - |