Assay Detail

CHEMBL615860

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Binding

Binding affinity towards human 5-hydroxytryptamine 1 receptor

ChEMBL ↗

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Target

5-hydroxytryptamine receptor 1A (CHEMBL214) ↗

Open DB target context

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5-hydroxytryptamine receptor 1A (CHEMBL214) is the working anchor for this assay review. Loading the live Open DB target snapshot…

Primary target 5-hydroxytryptamine receptor 1A

CHEMBL214

Anchored from Assay target.

Protein identity 5-hydroxytryptamine receptor 1A

Disease frame Disease evidence pending

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Review focus Open DB context pending

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Total Activities

Compounds Tested

Activity Types

Assay Parameters

Assay Information

Assay Type	Binding
Confidence	8 — Homologous single protein target
Curated By	Autocuration

Target

5-hydroxytryptamine receptor 1A (CHEMBL214) ↗

Type	SINGLE PROTEIN
Organism	Homo sapiens

Publication

Current and novel approaches to the drug treatment of schizophrenia.

Rowley M, Bristow LJ, Hutson PH.
J Med Chem (2001) 44 : 477 -501
PubMed 11170639 · DOI

Activity Statistics

Type	Count	Avg pChEMBL	Best pChEMBL
Ki	6	6.50	7.68

Compounds Tested

Compound	Name	Phase	Activities	Best pChEMBL
CHEMBL85	RISPERIDONE	4.0	1	7.68
CHEMBL708	ZIPRASIDONE	4.0	1	7.43
CHEMBL285802	ZOTEPINE	2.0	1	6.48
CHEMBL42	CLOZAPINE	4.0	1	6.15
CHEMBL716	QUETIAPINE	4.0	1	6.08
CHEMBL715	OLANZAPINE	4.0	1	5.15

Activity Data

Compound	Name	Type	Rel.	Value	Units	pChEMBL
CHEMBL85	RISPERIDONE	Ki	=	21.0	nM	7.68
CHEMBL708	ZIPRASIDONE	Ki	=	37.0	nM	7.43
CHEMBL285802	ZOTEPINE	Ki	=	330.0	nM	6.48
CHEMBL42	CLOZAPINE	Ki	=	710.0	nM	6.15
CHEMBL716	QUETIAPINE	Ki	=	830.0	nM	6.08
CHEMBL715	OLANZAPINE	Ki	=	7100.0	nM	5.15