Assay Detail
Binding
CHEMBL615880
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Binding affinity towards 5-hydroxytryptamine 1A receptor using receptor binding assay
26
Total Activities
26
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
Novel pyridazino[4,5-b][1,5]oxazepines and -thiazepines as 5-HT1A receptor ligands
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 26 | 7.16 | 8.15 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL49 | BUSPIRONE | 4.0 | 1 | 8.15 |
| CHEMBL56 | 8-OH-DPAT | — | 1 | 8.09 |
| CHEMBL318857 | — | — | 1 | 8.04 |
| CHEMBL316490 | — | — | 1 | 7.94 |
| CHEMBL319937 | — | — | 1 | 7.75 |
| CHEMBL95832 | — | — | 1 | 7.71 |
| CHEMBL318260 | — | — | 1 | 7.49 |
| CHEMBL95310 | — | — | 1 | 7.43 |
| CHEMBL95837 | — | — | 1 | 7.35 |
| CHEMBL95641 | — | — | 1 | 6.93 |
| CHEMBL100260 | — | — | 1 | 6.87 |
| CHEMBL318926 | — | — | 1 | 6.82 |
| CHEMBL97711 | — | — | 1 | 6.79 |
| CHEMBL318912 | — | — | 1 | 6.74 |
| CHEMBL329283 | — | — | 1 | 6.64 |
| CHEMBL97618 | — | — | 1 | 6.52 |
| CHEMBL431096 | — | — | 1 | 6.51 |
| CHEMBL99523 | — | — | 1 | 6.28 |
| CHEMBL316929 | — | — | 1 | 6.00 |
| CHEMBL319600 | — | — | 1 | - |
| CHEMBL95981 | — | — | 1 | - |
| CHEMBL99177 | — | — | 1 | - |
| CHEMBL97198 | — | — | 1 | - |
| CHEMBL95744 | — | — | 1 | - |
| CHEMBL97623 | — | — | 1 | - |
| CHEMBL95977 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL49 | BUSPIRONE | IC50 | = | 7.13 | nM | 8.15 |
| CHEMBL56 | 8-OH-DPAT | IC50 | = | 8.06 | nM | 8.09 |
| CHEMBL318857 | — | IC50 | = | 9.2 | nM | 8.04 |
| CHEMBL316490 | — | IC50 | = | 11.4 | nM | 7.94 |
| CHEMBL319937 | — | IC50 | = | 17.8 | nM | 7.75 |
| CHEMBL95832 | — | IC50 | = | 19.5 | nM | 7.71 |
| CHEMBL318260 | — | IC50 | = | 32.7 | nM | 7.49 |
| CHEMBL95310 | — | IC50 | = | 37.0 | nM | 7.43 |
| CHEMBL95837 | — | IC50 | = | 44.9 | nM | 7.35 |
| CHEMBL95641 | — | IC50 | = | 118.0 | nM | 6.93 |
| CHEMBL100260 | — | IC50 | = | 134.0 | nM | 6.87 |
| CHEMBL318926 | — | IC50 | = | 150.0 | nM | 6.82 |
| CHEMBL97711 | — | IC50 | = | 163.0 | nM | 6.79 |
| CHEMBL318912 | — | IC50 | = | 181.0 | nM | 6.74 |
| CHEMBL329283 | — | IC50 | = | 230.0 | nM | 6.64 |
| CHEMBL97618 | — | IC50 | = | 299.0 | nM | 6.52 |
| CHEMBL431096 | — | IC50 | = | 312.0 | nM | 6.51 |
| CHEMBL99523 | — | IC50 | = | 524.0 | nM | 6.28 |
| CHEMBL316929 | — | IC50 | = | 1003.0 | nM | 6.00 |
| CHEMBL319600 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL95981 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL99177 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL97198 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL95744 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL97623 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL95977 | — | IC50 | > | 1000.0 | nM | - |