Assay Detail
Binding
CHEMBL615900
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Affinity for 5-hydroxytryptamine 1A receptor labeled with [3H]8-OH-DPAT radioligand in hippocampus tissue
28
Total Activities
28
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Tissue | Hippocampus |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
Synthesis and biological evaluation of a series of substituted N-alkoxyimides and -amides as potential atypical antipsychotic agents.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 28 | 6.65 | 7.75 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL35057 | TIOSPIRONE | 2.0 | 1 | 7.75 |
| CHEMBL10355 | — | — | 1 | 7.52 |
| CHEMBL269176 | — | — | 1 | 7.52 |
| CHEMBL10821 | — | — | 1 | 7.40 |
| CHEMBL10963 | — | — | 1 | 7.30 |
| CHEMBL10640 | — | — | 1 | 7.22 |
| CHEMBL269458 | — | — | 1 | 7.16 |
| CHEMBL274334 | — | — | 1 | 7.10 |
| CHEMBL10875 | — | — | 1 | 7.05 |
| CHEMBL10366 | — | — | 1 | 6.96 |
| CHEMBL276175 | — | — | 1 | 6.96 |
| CHEMBL418526 | — | — | 1 | 6.77 |
| CHEMBL10880 | — | — | 1 | 6.66 |
| CHEMBL276378 | — | — | 1 | 6.43 |
| CHEMBL274306 | — | — | 1 | 6.42 |
| CHEMBL42 | CLOZAPINE | 4.0 | 1 | 6.24 |
| CHEMBL85 | RISPERIDONE | 4.0 | 1 | 6.09 |
| CHEMBL268267 | — | — | 1 | 6.01 |
| CHEMBL418340 | — | — | 1 | 5.66 |
| CHEMBL273505 | — | — | 1 | 5.56 |
| CHEMBL10682 | — | — | 1 | 5.28 |
| CHEMBL10907 | — | — | 1 | 5.16 |
| CHEMBL10658 | — | — | 1 | - |
| CHEMBL264472 | — | — | 1 | - |
| CHEMBL10194 | — | — | 1 | - |
| CHEMBL10692 | — | — | 1 | - |
| CHEMBL10623 | — | — | 1 | - |
| CHEMBL10546 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL35057 | TIOSPIRONE | IC50 | = | 18.0 | nM | 7.75 |
| CHEMBL10355 | — | IC50 | = | 30.0 | nM | 7.52 |
| CHEMBL269176 | — | IC50 | = | 30.0 | nM | 7.52 |
| CHEMBL10821 | — | IC50 | = | 40.0 | nM | 7.40 |
| CHEMBL10963 | — | IC50 | = | 50.0 | nM | 7.30 |
| CHEMBL10640 | — | IC50 | = | 60.0 | nM | 7.22 |
| CHEMBL269458 | — | IC50 | = | 70.0 | nM | 7.16 |
| CHEMBL274334 | — | IC50 | = | 80.0 | nM | 7.10 |
| CHEMBL10875 | — | IC50 | = | 90.0 | nM | 7.05 |
| CHEMBL10366 | — | IC50 | = | 110.0 | nM | 6.96 |
| CHEMBL276175 | — | IC50 | = | 110.0 | nM | 6.96 |
| CHEMBL418526 | — | IC50 | = | 170.0 | nM | 6.77 |
| CHEMBL10880 | — | IC50 | = | 220.0 | nM | 6.66 |
| CHEMBL276378 | — | IC50 | = | 370.0 | nM | 6.43 |
| CHEMBL274306 | — | IC50 | = | 380.0 | nM | 6.42 |
| CHEMBL42 | CLOZAPINE | IC50 | = | 580.0 | nM | 6.24 |
| CHEMBL85 | RISPERIDONE | IC50 | = | 820.0 | nM | 6.09 |
| CHEMBL268267 | — | IC50 | = | 970.0 | nM | 6.01 |
| CHEMBL418340 | — | IC50 | = | 2200.0 | nM | 5.66 |
| CHEMBL273505 | — | IC50 | = | 2760.0 | nM | 5.56 |
| CHEMBL10682 | — | IC50 | = | 5300.0 | nM | 5.28 |
| CHEMBL10907 | — | IC50 | = | 6900.0 | nM | 5.16 |
| CHEMBL10658 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL264472 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL10194 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL10692 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL10623 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL10546 | — | IC50 | > | 20000.0 | nM | - |