Assay Detail
Binding
CHEMBL615901
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of [3H]8-OH-DPAT binding at serotonin 5-hydroxytryptamine 1A receptor from rat hippocampus tissue.
21
Total Activities
21
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Tissue | Hippocampus |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
Effect of linking bridge modifications on the antipsychotic profile of some phthalimide and isoindolinone derivatives.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 21 | 7.42 | 9.72 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL290937 | — | — | 1 | 9.72 |
| CHEMBL38409 | — | — | 1 | 9.12 |
| CHEMBL41536 | — | — | 1 | 8.70 |
| CHEMBL41636 | — | — | 1 | 8.57 |
| CHEMBL290953 | — | — | 1 | 8.33 |
| CHEMBL41626 | — | — | 1 | 8.15 |
| CHEMBL39226 | — | — | 1 | 7.89 |
| CHEMBL288930 | — | — | 1 | 7.72 |
| CHEMBL291070 | — | — | 1 | 7.64 |
| CHEMBL43069 | — | — | 1 | 7.62 |
| CHEMBL36423 | — | — | 1 | 7.40 |
| CHEMBL43410 | — | — | 1 | 7.36 |
| CHEMBL289275 | — | — | 1 | 7.27 |
| CHEMBL38747 | — | — | 1 | 7.27 |
| CHEMBL41309 | — | — | 1 | 6.85 |
| CHEMBL288450 | — | — | 1 | 6.66 |
| CHEMBL441430 | — | — | 1 | 6.41 |
| CHEMBL43513 | — | — | 1 | 6.38 |
| CHEMBL559330 | — | — | 1 | 6.00 |
| CHEMBL42 | CLOZAPINE | 4.0 | 1 | 5.70 |
| CHEMBL54 | HALOPERIDOL | 4.0 | 1 | 5.16 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL290937 | — | IC50 | = | 0.19 | nM | 9.72 |
| CHEMBL38409 | — | IC50 | = | 0.76 | nM | 9.12 |
| CHEMBL41536 | — | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL41636 | — | IC50 | = | 2.7 | nM | 8.57 |
| CHEMBL290953 | — | IC50 | = | 4.7 | nM | 8.33 |
| CHEMBL41626 | — | IC50 | = | 7.0 | nM | 8.15 |
| CHEMBL39226 | — | IC50 | = | 13.0 | nM | 7.89 |
| CHEMBL288930 | — | IC50 | = | 19.0 | nM | 7.72 |
| CHEMBL291070 | — | IC50 | = | 23.0 | nM | 7.64 |
| CHEMBL43069 | — | IC50 | = | 24.0 | nM | 7.62 |
| CHEMBL36423 | — | IC50 | = | 40.0 | nM | 7.40 |
| CHEMBL43410 | — | IC50 | = | 44.0 | nM | 7.36 |
| CHEMBL289275 | — | IC50 | = | 54.0 | nM | 7.27 |
| CHEMBL38747 | — | IC50 | = | 54.0 | nM | 7.27 |
| CHEMBL41309 | — | IC50 | = | 140.0 | nM | 6.85 |
| CHEMBL288450 | — | IC50 | = | 220.0 | nM | 6.66 |
| CHEMBL441430 | — | IC50 | = | 390.0 | nM | 6.41 |
| CHEMBL43513 | — | IC50 | = | 420.0 | nM | 6.38 |
| CHEMBL559330 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL42 | CLOZAPINE | IC50 | = | 2000.0 | nM | 5.70 |
| CHEMBL54 | HALOPERIDOL | IC50 | = | 7000.0 | nM | 5.16 |