Assay Detail
Binding
CHEMBL615902
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In vitro inhibition of [3H]8-OH-DPAT binding to rat 5-HT 1a receptors.
20
Total Activities
20
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
1-aryl-4-[(5-methoxy-1,2,3, 4-tetrahydronaphthalen-1-yl)alkyl]piperazines and their analogues: influence of the stereochemistry of the tetrahydronaphthalen-1-yl nucleus on 5-HT1A receptor affinity and selectivity versus alpha1 and D2 receptors. 5.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 20 | 8.21 | 9.30 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL322275 | — | — | 1 | 9.30 |
| CHEMBL444590 | — | — | 1 | 9.27 |
| CHEMBL26929 | — | — | 1 | 9.11 |
| CHEMBL147659 | — | — | 1 | 8.89 |
| CHEMBL144523 | — | — | 1 | 8.80 |
| CHEMBL148288 | — | — | 1 | 8.64 |
| CHEMBL147861 | — | — | 1 | 8.62 |
| CHEMBL146942 | — | — | 1 | 8.60 |
| CHEMBL147963 | — | — | 1 | 8.37 |
| CHEMBL148186 | — | — | 1 | 8.35 |
| CHEMBL148234 | — | — | 1 | 8.15 |
| CHEMBL148397 | — | — | 1 | 8.15 |
| CHEMBL108241 | — | — | 1 | 8.11 |
| CHEMBL147371 | — | — | 1 | 8.00 |
| CHEMBL107486 | — | — | 1 | 8.00 |
| CHEMBL147692 | — | — | 1 | 7.47 |
| CHEMBL28063 | — | — | 1 | 7.42 |
| CHEMBL49 | BUSPIRONE | 4.0 | 1 | 7.30 |
| CHEMBL435029 | — | — | 1 | 7.05 |
| CHEMBL359245 | — | — | 1 | 6.50 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL322275 | — | IC50 | = | 0.5 | nM | 9.30 |
| CHEMBL444590 | — | IC50 | = | 0.54 | nM | 9.27 |
| CHEMBL26929 | — | IC50 | = | 0.77 | nM | 9.11 |
| CHEMBL147659 | — | IC50 | = | 1.3 | nM | 8.89 |
| CHEMBL144523 | — | IC50 | = | 1.6 | nM | 8.80 |
| CHEMBL148288 | — | IC50 | = | 2.3 | nM | 8.64 |
| CHEMBL147861 | — | IC50 | = | 2.4 | nM | 8.62 |
| CHEMBL146942 | — | IC50 | = | 2.5 | nM | 8.60 |
| CHEMBL147963 | — | IC50 | = | 4.3 | nM | 8.37 |
| CHEMBL148186 | — | IC50 | = | 4.5 | nM | 8.35 |
| CHEMBL148234 | — | IC50 | = | 7.0 | nM | 8.15 |
| CHEMBL148397 | — | IC50 | = | 7.0 | nM | 8.15 |
| CHEMBL108241 | — | IC50 | = | 7.7 | nM | 8.11 |
| CHEMBL147371 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL107486 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL147692 | — | IC50 | = | 34.0 | nM | 7.47 |
| CHEMBL28063 | — | IC50 | = | 38.0 | nM | 7.42 |
| CHEMBL49 | BUSPIRONE | IC50 | = | 50.0 | nM | 7.30 |
| CHEMBL435029 | — | IC50 | = | 89.0 | nM | 7.05 |
| CHEMBL359245 | — | IC50 | = | 320.0 | nM | 6.50 |