Assay Detail
Binding
CHEMBL615909
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In vitro affinity against 5-hydroxytryptamine 1A receptor using [3H]-8-OH-DPAT in rat hippocampus
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Tissue | Hippocampus |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Synthesis and in vitro and in vivo functional studies of ortho-substituted phenylpiperazine and N-substituted 4-N-(o-methoxyphenyl)aminopiperidine analogues of WAY100635.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 8 | 7.86 | 9.43 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL31354 | WAY-100,635 | — | 1 | 9.43 |
| CHEMBL137298 | — | — | 1 | 8.81 |
| CHEMBL423361 | — | — | 1 | 8.68 |
| CHEMBL342198 | — | — | 1 | 8.22 |
| CHEMBL335504 | — | — | 1 | 8.14 |
| CHEMBL139205 | — | — | 1 | 7.44 |
| CHEMBL136121 | — | — | 1 | 6.30 |
| CHEMBL136548 | — | — | 1 | 5.89 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL31354 | WAY-100,635 | IC50 | = | 0.37 | nM | 9.43 |
| CHEMBL137298 | — | IC50 | = | 1.55 | nM | 8.81 |
| CHEMBL423361 | — | IC50 | = | 2.1 | nM | 8.68 |
| CHEMBL342198 | — | IC50 | = | 6.05 | nM | 8.22 |
| CHEMBL335504 | — | IC50 | = | 7.25 | nM | 8.14 |
| CHEMBL139205 | — | IC50 | = | 36.0 | nM | 7.44 |
| CHEMBL136121 | — | IC50 | = | 500.0 | nM | 6.30 |
| CHEMBL136548 | — | IC50 | = | 1290.0 | nM | 5.89 |