Assay Detail
Binding
CHEMBL615913
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In vitro binding affinity for serotonin 5-hydroxytryptamine 1A receptor fof rat cerebral cortex using [3H]8-OH-DPAT as radioligand
20
Total Activities
20
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Tissue | Cerebral cortex |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
Synthesis and pharmacological evaluation of 1-[(1,2-diphenyl-1H-4-imidazolyl)methyl]-4-phenylpiperazines with clozapine-like mixed activities at dopamine D(2), serotonin, and GABA(A) receptors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 20 | 6.41 | 7.29 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL142147 | — | — | 1 | 7.29 |
| CHEMBL143744 | — | — | 1 | 7.25 |
| CHEMBL358316 | — | — | 1 | 7.13 |
| CHEMBL141824 | — | — | 1 | 6.78 |
| CHEMBL143372 | — | — | 1 | 6.77 |
| CHEMBL344796 | — | — | 1 | 6.71 |
| CHEMBL342119 | — | — | 1 | 6.69 |
| CHEMBL142825 | — | — | 1 | 6.65 |
| CHEMBL344084 | — | — | 1 | 6.59 |
| CHEMBL344202 | — | — | 1 | 6.57 |
| CHEMBL42 | CLOZAPINE | 4.0 | 1 | 6.57 |
| CHEMBL356993 | — | — | 1 | 6.48 |
| CHEMBL143218 | — | — | 1 | 6.28 |
| CHEMBL141077 | — | — | 1 | 6.09 |
| CHEMBL356116 | — | — | 1 | 5.95 |
| CHEMBL356068 | — | — | 1 | 5.72 |
| CHEMBL54 | HALOPERIDOL | 4.0 | 1 | 5.70 |
| CHEMBL142309 | — | — | 1 | 5.57 |
| CHEMBL341743 | — | — | 1 | 5.07 |
| CHEMBL344995 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL142147 | — | IC50 | = | 51.9 | nM | 7.29 |
| CHEMBL143744 | — | IC50 | = | 56.9 | nM | 7.25 |
| CHEMBL358316 | — | IC50 | = | 73.9 | nM | 7.13 |
| CHEMBL141824 | — | IC50 | = | 165.7 | nM | 6.78 |
| CHEMBL143372 | — | IC50 | = | 171.2 | nM | 6.77 |
| CHEMBL344796 | — | IC50 | = | 197.0 | nM | 6.71 |
| CHEMBL342119 | — | IC50 | = | 206.0 | nM | 6.69 |
| CHEMBL142825 | — | IC50 | = | 224.0 | nM | 6.65 |
| CHEMBL344084 | — | IC50 | = | 255.0 | nM | 6.59 |
| CHEMBL344202 | — | IC50 | = | 270.5 | nM | 6.57 |
| CHEMBL42 | CLOZAPINE | IC50 | = | 267.6 | nM | 6.57 |
| CHEMBL356993 | — | IC50 | = | 332.0 | nM | 6.48 |
| CHEMBL143218 | — | IC50 | = | 525.1 | nM | 6.28 |
| CHEMBL141077 | — | IC50 | = | 806.4 | nM | 6.09 |
| CHEMBL356116 | — | IC50 | = | 1127.0 | nM | 5.95 |
| CHEMBL356068 | — | IC50 | = | 1895.0 | nM | 5.72 |
| CHEMBL54 | HALOPERIDOL | IC50 | = | 1993.0 | nM | 5.70 |
| CHEMBL142309 | — | IC50 | = | 2704.0 | nM | 5.57 |
| CHEMBL341743 | — | IC50 | = | 8442.0 | nM | 5.07 |
| CHEMBL344995 | — | IC50 | > | 10000.0 | nM | - |