Assay Detail
Binding
CHEMBL615914
Review assay metadata, readout intent, target linkage, and publication context from the same page.
In vitro binding affinity measured on serotonin 5-hydroxytryptamine 1A receptor using [3H]8-OH-DPAT as radioligand.
31
Total Activities
31
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
High affinity and selectivity on 5-HT1A receptor of 1-aryl-4-[1-tetralin)alkyl]piperazines. 2.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 31 | 8.32 | 9.49 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL26929 | — | — | 1 | 9.49 |
| CHEMBL140406 | — | — | 1 | 9.46 |
| CHEMBL322275 | — | — | 1 | 9.44 |
| CHEMBL368477 | — | — | 1 | 9.41 |
| CHEMBL173190 | — | — | 1 | 9.28 |
| CHEMBL444590 | — | — | 1 | 9.24 |
| CHEMBL174703 | — | — | 1 | 8.97 |
| CHEMBL56 | 8-OH-DPAT | — | 1 | 8.96 |
| CHEMBL174083 | — | — | 1 | 8.95 |
| CHEMBL175300 | — | — | 1 | 8.85 |
| CHEMBL424125 | — | — | 1 | 8.82 |
| CHEMBL366459 | — | — | 1 | 8.81 |
| CHEMBL28209 | — | — | 1 | 8.76 |
| CHEMBL174300 | — | — | 1 | 8.73 |
| CHEMBL367435 | — | — | 1 | 8.70 |
| CHEMBL171181 | — | — | 1 | 8.47 |
| CHEMBL172556 | — | — | 1 | 8.23 |
| CHEMBL108241 | — | — | 1 | 8.15 |
| CHEMBL172161 | — | — | 1 | 8.06 |
| CHEMBL172363 | — | — | 1 | 8.05 |
| CHEMBL172601 | — | — | 1 | 8.03 |
| CHEMBL49 | BUSPIRONE | 4.0 | 1 | 7.89 |
| CHEMBL174554 | — | — | 1 | 7.89 |
| CHEMBL148055 | — | — | 1 | 7.74 |
| CHEMBL425134 | — | — | 1 | 7.39 |
| CHEMBL171974 | — | — | 1 | 7.25 |
| CHEMBL277302 | — | — | 1 | 7.20 |
| CHEMBL367723 | — | — | 1 | 7.05 |
| CHEMBL433972 | — | — | 1 | 6.86 |
| CHEMBL176819 | — | — | 1 | 6.84 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL26929 | — | IC50 | = | 0.32 | nM | 9.49 |
| CHEMBL140406 | — | IC50 | = | 0.35 | nM | 9.46 |
| CHEMBL322275 | — | IC50 | = | 0.36 | nM | 9.44 |
| CHEMBL368477 | — | IC50 | = | 0.39 | nM | 9.41 |
| CHEMBL173190 | — | IC50 | = | 0.52 | nM | 9.28 |
| CHEMBL444590 | — | IC50 | = | 0.58 | nM | 9.24 |
| CHEMBL174703 | — | IC50 | = | 1.08 | nM | 8.97 |
| CHEMBL56 | 8-OH-DPAT | IC50 | = | 1.1 | nM | 8.96 |
| CHEMBL174083 | — | IC50 | = | 1.13 | nM | 8.95 |
| CHEMBL175300 | — | IC50 | = | 1.4 | nM | 8.85 |
| CHEMBL424125 | — | IC50 | = | 1.5 | nM | 8.82 |
| CHEMBL366459 | — | IC50 | = | 1.53 | nM | 8.81 |
| CHEMBL28209 | — | IC50 | = | 1.73 | nM | 8.76 |
| CHEMBL174300 | — | IC50 | = | 1.84 | nM | 8.73 |
| CHEMBL367435 | — | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL171181 | — | IC50 | = | 3.38 | nM | 8.47 |
| CHEMBL172556 | — | IC50 | = | 5.94 | nM | 8.23 |
| CHEMBL108241 | — | IC50 | = | 7.01 | nM | 8.15 |
| CHEMBL172161 | — | IC50 | = | 8.8 | nM | 8.06 |
| CHEMBL172363 | — | IC50 | = | 8.83 | nM | 8.05 |
| CHEMBL172601 | — | IC50 | = | 9.24 | nM | 8.03 |
| CHEMBL49 | BUSPIRONE | IC50 | = | 12.8 | nM | 7.89 |
| CHEMBL174554 | — | IC50 | = | 13.0 | nM | 7.89 |
| CHEMBL148055 | — | IC50 | = | 18.3 | nM | 7.74 |
| CHEMBL425134 | — | IC50 | = | 40.3 | nM | 7.39 |
| CHEMBL171974 | — | IC50 | = | 55.9 | nM | 7.25 |
| CHEMBL277302 | — | IC50 | = | 63.6 | nM | 7.20 |
| CHEMBL367723 | — | IC50 | = | 88.4 | nM | 7.05 |
| CHEMBL433972 | — | IC50 | = | 138.0 | nM | 6.86 |
| CHEMBL176819 | — | IC50 | = | 146.0 | nM | 6.84 |
| CHEMBL143110 | — | IC50 | = | 147.0 | nM | 6.83 |