Assay Detail
Binding
CHEMBL615916
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In vitro binding affinity towards the 5-hydroxytryptamine 1A receptor was evaluated
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
(S)-N-tert-butyl-3-(4-(2-methoxyphenyl)-piperazin-1-yl)-2-phenylpropanamide [(S)-WAY-100135]: a selective antagonist at presynaptic and postsynaptic 5-HT1A receptors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 7.32 | 7.81 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL38288 | — | — | 1 | 7.81 |
| CHEMBL49 | BUSPIRONE | 4.0 | 1 | 7.62 |
| CHEMBL22564 | — | — | 1 | 7.47 |
| CHEMBL289981 | — | — | 1 | 6.36 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL38288 | — | IC50 | = | 15.5 | nM | 7.81 |
| CHEMBL49 | BUSPIRONE | IC50 | = | 24.0 | nM | 7.62 |
| CHEMBL22564 | — | IC50 | = | 33.9 | nM | 7.47 |
| CHEMBL289981 | — | IC50 | = | 437.0 | nM | 6.36 |