Assay Detail
Binding
CHEMBL615917
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In vitro binding affinity was measured on serotonergic 5-hydroxytryptamine 1A receptor by displacement of [3H]- tetralin
18
Total Activities
17
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
Cyclic benzamides as mixed dopamine D2/serotonin 5-HT2 receptor antagonists: potential atypical antipsychotic agents.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 18 | 8.23 | 10.68 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL83625 | — | — | 2 | 10.68 |
| CHEMBL290937 | — | — | 1 | 9.72 |
| CHEMBL87294 | — | — | 1 | 9.40 |
| CHEMBL314370 | — | — | 1 | 9.23 |
| CHEMBL86013 | — | — | 1 | 9.19 |
| CHEMBL314043 | — | — | 1 | 8.77 |
| CHEMBL83454 | — | — | 1 | 8.74 |
| CHEMBL85137 | — | — | 1 | 8.59 |
| CHEMBL83195 | — | — | 1 | 8.47 |
| CHEMBL315925 | — | — | 1 | 8.39 |
| CHEMBL41626 | — | — | 1 | 8.15 |
| CHEMBL85647 | — | — | 1 | 8.00 |
| CHEMBL83510 | — | — | 1 | 7.48 |
| CHEMBL314684 | — | — | 1 | 6.92 |
| CHEMBL3144650 | — | — | 1 | 6.46 |
| CHEMBL42 | CLOZAPINE | 4.0 | 1 | 5.70 |
| CHEMBL54 | HALOPERIDOL | 4.0 | 1 | 5.16 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL83625 | — | IC50 | = | 0.021 | nM | 10.68 |
| CHEMBL290937 | — | IC50 | = | 0.19 | nM | 9.72 |
| CHEMBL87294 | — | IC50 | = | 0.4 | nM | 9.40 |
| CHEMBL314370 | — | IC50 | = | 0.59 | nM | 9.23 |
| CHEMBL86013 | — | IC50 | = | 0.64 | nM | 9.19 |
| CHEMBL83625 | — | IC50 | = | 0.82 | nM | 9.09 |
| CHEMBL314043 | — | IC50 | = | 1.7 | nM | 8.77 |
| CHEMBL83454 | — | IC50 | = | 1.8 | nM | 8.74 |
| CHEMBL85137 | — | IC50 | = | 2.6 | nM | 8.59 |
| CHEMBL83195 | — | IC50 | = | 3.4 | nM | 8.47 |
| CHEMBL315925 | — | IC50 | = | 4.1 | nM | 8.39 |
| CHEMBL41626 | — | IC50 | = | 7.0 | nM | 8.15 |
| CHEMBL85647 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL83510 | — | IC50 | = | 33.0 | nM | 7.48 |
| CHEMBL314684 | — | IC50 | = | 120.0 | nM | 6.92 |
| CHEMBL3144650 | — | IC50 | = | 350.0 | nM | 6.46 |
| CHEMBL42 | CLOZAPINE | IC50 | = | 2000.0 | nM | 5.70 |
| CHEMBL54 | HALOPERIDOL | IC50 | = | 7000.0 | nM | 5.16 |