Assay Detail
Functional
CHEMBL615924
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Inhibition of forskolin-activated adenylate cyclase (cAMP) activity at 5-hydroxytryptamine 1A receptor in rat hippocampus
5
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Tissue | Hippocampus |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
New benzocycloalkylpiperazines, potent and selective 5-HT1A receptor ligands.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 7.42 | 7.85 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL354210 | — | — | 2 | 7.85 |
| CHEMBL56 | 8-OH-DPAT | — | 1 | 7.85 |
| CHEMBL49 | BUSPIRONE | 4.0 | 1 | 7.28 |
| CHEMBL366388 | — | — | 1 | 6.68 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL354210 | — | IC50 | = | 14.0 | nM | 7.85 |
| CHEMBL56 | 8-OH-DPAT | IC50 | = | 14.0 | nM | 7.85 |
| CHEMBL354210 | — | IC50 | = | 36.0 | nM | 7.44 |
| CHEMBL49 | BUSPIRONE | IC50 | = | 52.0 | nM | 7.28 |
| CHEMBL366388 | — | IC50 | = | 210.0 | nM | 6.68 |