Assay Detail
Functional
CHEMBL615925
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Inhibition of forskolin-activated adenylate cyclase (cAMP) activity at 5-hydroxytryptamine 1A receptor in rat hippocampus
6
Total Activities
2
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Tissue | Hippocampus |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
New benzocycloalkylpiperazines, potent and selective 5-HT1A receptor ligands.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 6.88 | 7.82 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL368061 | — | — | 3 | 7.82 |
| CHEMBL177031 | — | — | 3 | 7.42 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL368061 | — | IC50 | = | 15.0 | nM | 7.82 |
| CHEMBL177031 | — | IC50 | = | 38.0 | nM | 7.42 |
| CHEMBL368061 | — | IC50 | = | 52.0 | nM | 7.28 |
| CHEMBL177031 | — | IC50 | = | 75.0 | nM | 7.12 |
| CHEMBL368061 | — | IC50 | = | 1450.0 | nM | 5.84 |
| CHEMBL177031 | — | IC50 | = | 1500.0 | nM | 5.82 |