Assay Detail
Binding
CHEMBL615927
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement of [3H]8-OH-DPAT from rat cortex 5-hydroxytryptamine 1A receptor
13
Total Activities
13
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
3-(1,2,5,6-Tetrahydropyrid-4-yl)pyrrolo[3,2-b]pyrid-5-one: a potent and selective serotonin (5-HT1B) agonist and rotationally restricted phenolic analogue of 5-methoxy-3-(1,2,5,6-tetrahydropyrid-4-yl)indole.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 13 | 7.33 | 8.28 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL39 | SEROTONIN | 3.0 | 1 | 8.28 |
| CHEMBL27592 | — | — | 1 | 7.89 |
| CHEMBL18785 | RU-24969 | — | 1 | 7.85 |
| CHEMBL27403 | — | — | 1 | 7.72 |
| CHEMBL282994 | — | — | 1 | 7.58 |
| CHEMBL26378 | — | — | 1 | 7.52 |
| CHEMBL26379 | — | — | 1 | 7.50 |
| CHEMBL283257 | — | — | 1 | 7.44 |
| CHEMBL28178 | — | — | 1 | 7.43 |
| CHEMBL26906 | — | — | 1 | 7.19 |
| CHEMBL27811 | — | — | 1 | 6.85 |
| CHEMBL274866 | — | — | 1 | 6.54 |
| CHEMBL304008 | — | — | 1 | 5.52 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL39 | SEROTONIN | IC50 | = | 5.2 | nM | 8.28 |
| CHEMBL27592 | — | IC50 | = | 13.0 | nM | 7.89 |
| CHEMBL18785 | RU-24969 | IC50 | = | 14.0 | nM | 7.85 |
| CHEMBL27403 | — | IC50 | = | 19.0 | nM | 7.72 |
| CHEMBL282994 | — | IC50 | = | 26.0 | nM | 7.58 |
| CHEMBL26378 | — | IC50 | = | 30.0 | nM | 7.52 |
| CHEMBL26379 | — | IC50 | = | 32.0 | nM | 7.50 |
| CHEMBL283257 | — | IC50 | = | 36.0 | nM | 7.44 |
| CHEMBL28178 | — | IC50 | = | 37.0 | nM | 7.43 |
| CHEMBL26906 | — | IC50 | = | 65.0 | nM | 7.19 |
| CHEMBL27811 | — | IC50 | = | 140.0 | nM | 6.85 |
| CHEMBL274866 | — | IC50 | = | 290.0 | nM | 6.54 |
| CHEMBL304008 | — | IC50 | = | 3000.0 | nM | 5.52 |