Assay Detail
Binding
CHEMBL615929
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Inhibitory activity against 5-hydroxytryptamine 1A receptor subtype
10
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Bivalent indoles exhibiting serotonergic binding affinity
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 10 | 8.73 | 9.89 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL22960 | — | — | 1 | 9.89 |
| CHEMBL281575 | — | — | 1 | 9.66 |
| CHEMBL417650 | — | — | 1 | 8.90 |
| CHEMBL22744 | — | — | 1 | 8.74 |
| CHEMBL22553 | — | — | 1 | 8.70 |
| CHEMBL22961 | — | — | 1 | 8.67 |
| CHEMBL21862 | — | — | 1 | 8.64 |
| CHEMBL17828 | — | — | 1 | 8.54 |
| CHEMBL277452 | — | — | 1 | 7.84 |
| CHEMBL278610 | — | — | 1 | 7.75 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL22960 | — | IC50 | = | 0.13 | nM | 9.89 |
| CHEMBL281575 | — | IC50 | = | 0.22 | nM | 9.66 |
| CHEMBL417650 | — | IC50 | = | 1.27 | nM | 8.90 |
| CHEMBL22744 | — | IC50 | = | 1.83 | nM | 8.74 |
| CHEMBL22553 | — | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL22961 | — | IC50 | = | 2.13 | nM | 8.67 |
| CHEMBL21862 | — | IC50 | = | 2.27 | nM | 8.64 |
| CHEMBL17828 | — | IC50 | = | 2.86 | nM | 8.54 |
| CHEMBL277452 | — | IC50 | = | 14.5 | nM | 7.84 |
| CHEMBL278610 | — | IC50 | = | 18.0 | nM | 7.75 |