Assay Detail
Binding
CHEMBL615931
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Inhibition concentration against 5-hydroxytryptamine 1A receptor using cAMP as radioligand in CHO cells
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Cell Type | CHO |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Studies toward the discovery of the next generation of antidepressants. 3. Dual 5-HT1A and serotonin transporter affinity within a class of N-aryloxyethylindolylalkylamines.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 6.76 | 7.31 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL124069 | — | — | 1 | 7.31 |
| CHEMBL338520 | — | — | 1 | 6.62 |
| CHEMBL339810 | — | — | 1 | 6.35 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL124069 | — | IC50 | = | 49.0 | nM | 7.31 |
| CHEMBL338520 | — | IC50 | = | 238.0 | nM | 6.62 |
| CHEMBL339810 | — | IC50 | = | 445.0 | nM | 6.35 |