Assay Detail
Binding
CHEMBL615939
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In vitro displacement of [3H]8-OH-DPAT binding to rat hippocampal 5-hydroxytryptamine 1A receptor
21
Total Activities
21
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Tissue | Hippocampus |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
11-substituted (R)-aporphines: synthesis, pharmacology, and modeling of D2A and 5-HT1A receptor interactions.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 21 | 7.48 | 8.74 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL25924 | — | — | 1 | 8.74 |
| CHEMBL118254 | — | — | 1 | 8.35 |
| CHEMBL117841 | — | — | 1 | 8.29 |
| CHEMBL332332 | — | — | 1 | 8.24 |
| CHEMBL119656 | — | — | 1 | 8.22 |
| CHEMBL333836 | — | — | 1 | 8.11 |
| CHEMBL119132 | — | — | 1 | 8.08 |
| CHEMBL119455 | — | — | 1 | 8.02 |
| CHEMBL27940 | — | — | 1 | 7.84 |
| CHEMBL333085 | — | — | 1 | 7.57 |
| CHEMBL119154 | — | — | 1 | 7.50 |
| CHEMBL27559 | — | — | 1 | 7.40 |
| CHEMBL115969 | — | — | 1 | 7.39 |
| CHEMBL333134 | — | — | 1 | 7.24 |
| CHEMBL281357 | — | — | 1 | 7.10 |
| CHEMBL324073 | — | — | 1 | 6.70 |
| CHEMBL53 | APOMORPHINE | 4.0 | 1 | 6.53 |
| CHEMBL115402 | — | — | 1 | 6.43 |
| CHEMBL333725 | — | — | 1 | 6.36 |
| CHEMBL119401 | — | — | 1 | 5.49 |
| CHEMBL119384 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL25924 | — | Ki | = | 1.8 | nM | 8.74 |
| CHEMBL118254 | — | Ki | = | 4.5 | nM | 8.35 |
| CHEMBL117841 | — | Ki | = | 5.1 | nM | 8.29 |
| CHEMBL332332 | — | Ki | = | 5.7 | nM | 8.24 |
| CHEMBL119656 | — | Ki | = | 6.0 | nM | 8.22 |
| CHEMBL333836 | — | Ki | = | 7.7 | nM | 8.11 |
| CHEMBL119132 | — | Ki | = | 8.3 | nM | 8.08 |
| CHEMBL119455 | — | Ki | = | 9.6 | nM | 8.02 |
| CHEMBL27940 | — | Ki | = | 14.4 | nM | 7.84 |
| CHEMBL333085 | — | Ki | = | 26.9 | nM | 7.57 |
| CHEMBL119154 | — | Ki | = | 31.3 | nM | 7.50 |
| CHEMBL27559 | — | Ki | = | 39.5 | nM | 7.40 |
| CHEMBL115969 | — | Ki | = | 41.1 | nM | 7.39 |
| CHEMBL333134 | — | Ki | = | 57.1 | nM | 7.24 |
| CHEMBL281357 | — | Ki | = | 80.0 | nM | 7.10 |
| CHEMBL324073 | — | Ki | = | 198.0 | nM | 6.70 |
| CHEMBL53 | APOMORPHINE | Ki | = | 296.0 | nM | 6.53 |
| CHEMBL115402 | — | Ki | = | 375.0 | nM | 6.43 |
| CHEMBL333725 | — | Ki | = | 437.0 | nM | 6.36 |
| CHEMBL119401 | — | Ki | = | 3220.0 | nM | 5.49 |
| CHEMBL119384 | — | Ki | > | 5000.0 | nM | - |