Assay Detail
Binding
CHEMBL615940
Review assay metadata, readout intent, target linkage, and publication context from the same page.
In vitro ability to displace [3H]8-OH-DPAT from 5-hydroxytryptamine 1A receptor sites of rat brain cortex.
32
Total Activities
32
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
New (2-methoxyphenyl)piperazine derivatives as 5-HT1A receptor ligands with reduced alpha 1-adrenergic activity. Synthesis and structure-affinity relationships.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 32 | 8.35 | 9.92 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL23847 | — | — | 1 | 9.92 |
| CHEMBL22482 | — | — | 1 | 9.64 |
| CHEMBL25654 | — | — | 1 | 9.62 |
| CHEMBL23946 | — | — | 1 | 9.57 |
| CHEMBL22600 | — | — | 1 | 9.42 |
| CHEMBL23877 | — | — | 1 | 9.20 |
| CHEMBL23505 | — | — | 1 | 9.13 |
| CHEMBL56 | 8-OH-DPAT | — | 1 | 8.93 |
| CHEMBL282453 | — | — | 1 | 8.92 |
| CHEMBL8618 | NAN-190 | — | 1 | 8.90 |
| CHEMBL22427 | — | — | 1 | 8.81 |
| CHEMBL23904 | — | — | 1 | 8.73 |
| CHEMBL282012 | — | — | 1 | 8.66 |
| CHEMBL22601 | — | — | 1 | 8.64 |
| CHEMBL23449 | — | — | 1 | 8.63 |
| CHEMBL22871 | — | — | 1 | 8.51 |
| CHEMBL23315 | — | — | 1 | 8.48 |
| CHEMBL23266 | — | — | 1 | 8.42 |
| CHEMBL23905 | — | — | 1 | 8.33 |
| CHEMBL276953 | — | — | 1 | 8.17 |
| CHEMBL280426 | — | — | 1 | 7.94 |
| CHEMBL278604 | — | — | 1 | 7.90 |
| CHEMBL49 | BUSPIRONE | 4.0 | 1 | 7.81 |
| CHEMBL22872 | — | — | 1 | 7.76 |
| CHEMBL278799 | — | — | 1 | 7.69 |
| CHEMBL23912 | — | — | 1 | 7.60 |
| CHEMBL23530 | — | — | 1 | 7.49 |
| CHEMBL23817 | — | — | 1 | 7.49 |
| CHEMBL442065 | — | — | 1 | 7.25 |
| CHEMBL23264 | — | — | 1 | 6.70 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL23847 | — | Ki | = | 0.12 | nM | 9.92 |
| CHEMBL22482 | — | Ki | = | 0.23 | nM | 9.64 |
| CHEMBL25654 | — | Ki | = | 0.24 | nM | 9.62 |
| CHEMBL23946 | — | Ki | = | 0.27 | nM | 9.57 |
| CHEMBL22600 | — | Ki | = | 0.38 | nM | 9.42 |
| CHEMBL23877 | — | Ki | = | 0.63 | nM | 9.20 |
| CHEMBL23505 | — | Ki | = | 0.74 | nM | 9.13 |
| CHEMBL56 | 8-OH-DPAT | Ki | = | 1.18 | nM | 8.93 |
| CHEMBL282453 | — | Ki | = | 1.19 | nM | 8.92 |
| CHEMBL8618 | NAN-190 | Ki | = | 1.26 | nM | 8.90 |
| CHEMBL22427 | — | Ki | = | 1.53 | nM | 8.81 |
| CHEMBL23904 | — | Ki | = | 1.88 | nM | 8.73 |
| CHEMBL282012 | — | Ki | = | 2.2 | nM | 8.66 |
| CHEMBL22601 | — | Ki | = | 2.29 | nM | 8.64 |
| CHEMBL23449 | — | Ki | = | 2.34 | nM | 8.63 |
| CHEMBL22871 | — | Ki | = | 3.09 | nM | 8.51 |
| CHEMBL23315 | — | Ki | = | 3.34 | nM | 8.48 |
| CHEMBL23266 | — | Ki | = | 3.8 | nM | 8.42 |
| CHEMBL23905 | — | Ki | = | 4.68 | nM | 8.33 |
| CHEMBL276953 | — | Ki | = | 6.83 | nM | 8.17 |
| CHEMBL280426 | — | Ki | = | 11.6 | nM | 7.94 |
| CHEMBL278604 | — | Ki | = | 12.5 | nM | 7.90 |
| CHEMBL49 | BUSPIRONE | Ki | = | 15.4 | nM | 7.81 |
| CHEMBL22872 | — | Ki | = | 17.5 | nM | 7.76 |
| CHEMBL278799 | — | Ki | = | 20.3 | nM | 7.69 |
| CHEMBL23912 | — | Ki | = | 25.2 | nM | 7.60 |
| CHEMBL23530 | — | Ki | = | 32.13 | nM | 7.49 |
| CHEMBL23817 | — | Ki | = | 32.3 | nM | 7.49 |
| CHEMBL442065 | — | Ki | = | 55.71 | nM | 7.25 |
| CHEMBL23264 | — | Ki | = | 201.0 | nM | 6.70 |
| CHEMBL24113 | — | Ki | = | 321.0 | nM | 6.49 |
| CHEMBL26447 | — | Ki | = | 362.0 | nM | 6.44 |