Assay Detail
Binding
CHEMBL615958
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement of [3H]2-(di-N-propylamino)-8-hydroxytetralin from central 5-hydroxytryptamine 1A receptor recognition sites in rat frontal cortex homogenates.
29
Total Activities
29
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Tissue | Frontal cortex |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
N4-unsubstituted N1-arylpiperazines as high-affinity 5-HT1A receptor ligands.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 29 | 7.07 | 8.28 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL294456 | — | — | 1 | 8.28 |
| CHEMBL61242 | — | — | 1 | 8.24 |
| CHEMBL60809 | — | — | 1 | 8.00 |
| CHEMBL434784 | — | — | 1 | 7.92 |
| CHEMBL61028 | — | — | 1 | 7.89 |
| CHEMBL61032 | — | — | 1 | 7.89 |
| CHEMBL277120 | — | — | 1 | 7.75 |
| CHEMBL305308 | — | — | 1 | 7.75 |
| CHEMBL57583 | — | — | 1 | 7.55 |
| CHEMBL301049 | — | — | 1 | 7.46 |
| CHEMBL282614 | ELTOPRAZINE | 2.0 | 1 | 7.40 |
| CHEMBL301451 | — | — | 1 | 7.14 |
| CHEMBL301644 | — | — | 1 | 7.08 |
| CHEMBL432134 | — | — | 1 | 6.98 |
| CHEMBL291572 | — | — | 1 | 6.92 |
| CHEMBL59340 | — | — | 1 | 6.89 |
| CHEMBL62195 | — | — | 1 | 6.85 |
| CHEMBL9666 | — | — | 1 | 6.77 |
| CHEMBL60803 | — | — | 1 | 6.70 |
| CHEMBL60341 | — | — | 1 | 6.70 |
| CHEMBL59396 | — | — | 1 | 6.66 |
| CHEMBL303771 | — | — | 1 | 6.66 |
| CHEMBL58591 | — | — | 1 | 6.52 |
| CHEMBL59597 | — | — | 1 | 6.50 |
| CHEMBL61438 | — | — | 1 | 6.37 |
| CHEMBL9434 | PHENYLPIPERAZINE | — | 1 | 6.30 |
| CHEMBL58963 | — | — | 1 | 6.00 |
| CHEMBL59517 | — | — | 1 | 4.70 |
| CHEMBL60340 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL294456 | — | Ki | = | 5.2 | nM | 8.28 |
| CHEMBL61242 | — | Ki | = | 5.8 | nM | 8.24 |
| CHEMBL60809 | — | Ki | = | 9.9 | nM | 8.00 |
| CHEMBL434784 | — | Ki | = | 12.0 | nM | 7.92 |
| CHEMBL61028 | — | Ki | = | 13.0 | nM | 7.89 |
| CHEMBL61032 | — | Ki | = | 13.0 | nM | 7.89 |
| CHEMBL277120 | — | Ki | = | 18.0 | nM | 7.75 |
| CHEMBL305308 | — | Ki | = | 18.0 | nM | 7.75 |
| CHEMBL57583 | — | Ki | = | 28.0 | nM | 7.55 |
| CHEMBL301049 | — | Ki | = | 35.0 | nM | 7.46 |
| CHEMBL282614 | ELTOPRAZINE | Ki | = | 40.0 | nM | 7.40 |
| CHEMBL301451 | — | Ki | = | 73.0 | nM | 7.14 |
| CHEMBL301644 | — | Ki | = | 84.0 | nM | 7.08 |
| CHEMBL432134 | — | Ki | = | 105.0 | nM | 6.98 |
| CHEMBL291572 | — | Ki | = | 120.0 | nM | 6.92 |
| CHEMBL59340 | — | Ki | = | 130.0 | nM | 6.89 |
| CHEMBL62195 | — | Ki | = | 140.0 | nM | 6.85 |
| CHEMBL9666 | — | Ki | = | 170.0 | nM | 6.77 |
| CHEMBL60803 | — | Ki | = | 200.0 | nM | 6.70 |
| CHEMBL60341 | — | Ki | = | 200.0 | nM | 6.70 |
| CHEMBL59396 | — | Ki | = | 220.0 | nM | 6.66 |
| CHEMBL303771 | — | Ki | = | 220.0 | nM | 6.66 |
| CHEMBL58591 | — | Ki | = | 300.0 | nM | 6.52 |
| CHEMBL59597 | — | Ki | = | 320.0 | nM | 6.50 |
| CHEMBL61438 | — | Ki | = | 430.0 | nM | 6.37 |
| CHEMBL9434 | PHENYLPIPERAZINE | Ki | = | 500.0 | nM | 6.30 |
| CHEMBL58963 | — | Ki | = | 1000.0 | nM | 6.00 |
| CHEMBL59517 | — | Ki | = | 20000.0 | nM | 4.70 |
| CHEMBL60340 | — | Ki | > | 10000.0 | nM | - |