Assay Detail
Binding
CHEMBL615962
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Evaluated for binding affinity towards 5-hydroxytryptamine 1A receptor in rat brain
22
Total Activities
22
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Tissue | Brain |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
Arylpiperazine derivatives as high-affinity 5-HT1A serotonin ligands.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 22 | 7.22 | 9.22 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL8618 | NAN-190 | — | 1 | 9.22 |
| CHEMBL26587 | — | — | 1 | 9.00 |
| CHEMBL26188 | — | — | 1 | 8.70 |
| CHEMBL292204 | — | — | 1 | 8.07 |
| CHEMBL440466 | — | — | 1 | 8.00 |
| CHEMBL277120 | — | — | 1 | 7.96 |
| CHEMBL49 | BUSPIRONE | 4.0 | 1 | 7.82 |
| CHEMBL281720 | — | — | 1 | 7.44 |
| CHEMBL27526 | — | — | 1 | 7.22 |
| CHEMBL9666 | — | — | 1 | 7.17 |
| CHEMBL284092 | GEPIRONE | 4.0 | 1 | 7.16 |
| CHEMBL478 | CHLOROPHENYLPIPERAZINE | 2.0 | 1 | 6.89 |
| CHEMBL274866 | — | — | 1 | 6.76 |
| CHEMBL27310 | — | — | 1 | 6.70 |
| CHEMBL27555 | — | — | 1 | 6.60 |
| CHEMBL9434 | PHENYLPIPERAZINE | — | 1 | 6.42 |
| CHEMBL61778 | — | — | 1 | 6.06 |
| CHEMBL724 | 2-PIPERAZIN-1-YL-PYRIMIDINE | — | 1 | 5.85 |
| CHEMBL20969 | — | — | 1 | 5.82 |
| CHEMBL278509 | — | — | 1 | 5.54 |
| CHEMBL26952 | — | — | 1 | - |
| CHEMBL26718 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL8618 | NAN-190 | Ki | = | 0.6 | nM | 9.22 |
| CHEMBL26587 | — | Ki | = | 1.0 | nM | 9.00 |
| CHEMBL26188 | — | Ki | = | 2.0 | nM | 8.70 |
| CHEMBL292204 | — | Ki | = | 8.5 | nM | 8.07 |
| CHEMBL440466 | — | Ki | = | 10.0 | nM | 8.00 |
| CHEMBL277120 | — | Ki | = | 11.0 | nM | 7.96 |
| CHEMBL49 | BUSPIRONE | Ki | = | 15.0 | nM | 7.82 |
| CHEMBL281720 | — | Ki | = | 36.0 | nM | 7.44 |
| CHEMBL27526 | — | Ki | = | 60.0 | nM | 7.22 |
| CHEMBL9666 | — | Ki | = | 68.0 | nM | 7.17 |
| CHEMBL284092 | GEPIRONE | Ki | = | 70.0 | nM | 7.16 |
| CHEMBL478 | CHLOROPHENYLPIPERAZINE | Ki | = | 130.0 | nM | 6.89 |
| CHEMBL274866 | — | Ki | = | 175.0 | nM | 6.76 |
| CHEMBL27310 | — | Ki | = | 200.0 | nM | 6.70 |
| CHEMBL27555 | — | Ki | = | 250.0 | nM | 6.60 |
| CHEMBL9434 | PHENYLPIPERAZINE | Ki | = | 380.0 | nM | 6.42 |
| CHEMBL61778 | — | Ki | = | 870.0 | nM | 6.06 |
| CHEMBL724 | 2-PIPERAZIN-1-YL-PYRIMIDINE | Ki | = | 1410.0 | nM | 5.85 |
| CHEMBL20969 | — | Ki | = | 1520.0 | nM | 5.82 |
| CHEMBL278509 | — | Ki | = | 2900.0 | nM | 5.54 |
| CHEMBL26952 | — | Ki | > | 10000.0 | nM | - |
| CHEMBL26718 | — | Ki | > | 6000.0 | nM | - |