Assay Detail
Binding
CHEMBL615963
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Evaluated for the binding affinity to hippocampus striatal membranes at 5-hydroxytryptamine 1A receptor binding site by using [3H]-8-OH- DPAT as a radioligand.
23
Total Activities
23
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Tissue | Striatum |
| Subcellular | Membrane |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
Central serotonin receptors as targets for drug research.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 23 | 7.16 | 9.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL18840 | — | — | 1 | 9.70 |
| CHEMBL56 | 8-OH-DPAT | — | 1 | 8.70 |
| CHEMBL39 | SEROTONIN | 3.0 | 1 | 8.52 |
| CHEMBL18785 | RU-24969 | — | 1 | 8.30 |
| CHEMBL277362 | — | — | 1 | 8.30 |
| CHEMBL19215 | METERGOLINE | 2.0 | 1 | 8.22 |
| CHEMBL8165 | 5-METHOXYTRYPTAMINE | — | 1 | 8.05 |
| CHEMBL7257 | MEBUFOTENIN | 2.0 | 1 | 7.70 |
| CHEMBL500 | PINDOLOL | 4.0 | 1 | 7.70 |
| CHEMBL267930 | SPIPERONE | 2.0 | 1 | 7.40 |
| CHEMBL275854 | — | — | 1 | 7.07 |
| CHEMBL18855 | — | — | 1 | 7.02 |
| CHEMBL452861 | LEVOPROPRANOLOL | 2.0 | 1 | 6.94 |
| CHEMBL6640 | TRYPTAMINE | — | 1 | 6.77 |
| CHEMBL416526 | BUFOTENINE | — | 1 | 6.59 |
| CHEMBL12314 | MESULERGINE | 2.0 | 1 | 6.52 |
| CHEMBL19264 | — | — | 1 | 5.80 |
| CHEMBL18331 | PIRENPERONE | 2.0 | 1 | 5.77 |
| CHEMBL51 | KETANSERIN | 3.0 | 1 | 5.72 |
| CHEMBL274866 | — | — | 1 | 5.71 |
| CHEMBL478 | CHLOROPHENYLPIPERAZINE | 2.0 | 1 | 5.62 |
| CHEMBL18772 | QUIPAZINE | 2.0 | 1 | 5.48 |
| CHEMBL134519 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL18840 | — | Ki | = | 0.2 | nM | 9.70 |
| CHEMBL56 | 8-OH-DPAT | Ki | = | 2.0 | nM | 8.70 |
| CHEMBL39 | SEROTONIN | Ki | = | 3.0 | nM | 8.52 |
| CHEMBL18785 | RU-24969 | Ki | = | 5.0 | nM | 8.30 |
| CHEMBL277362 | — | Ki | = | 5.0 | nM | 8.30 |
| CHEMBL19215 | METERGOLINE | Ki | = | 6.0 | nM | 8.22 |
| CHEMBL8165 | 5-METHOXYTRYPTAMINE | Ki | = | 9.0 | nM | 8.05 |
| CHEMBL7257 | MEBUFOTENIN | Ki | = | 20.0 | nM | 7.70 |
| CHEMBL500 | PINDOLOL | Ki | = | 20.0 | nM | 7.70 |
| CHEMBL267930 | SPIPERONE | Ki | = | 40.0 | nM | 7.40 |
| CHEMBL275854 | — | Ki | = | 85.0 | nM | 7.07 |
| CHEMBL18855 | — | Ki | = | 95.0 | nM | 7.02 |
| CHEMBL452861 | LEVOPROPRANOLOL | Ki | = | 115.0 | nM | 6.94 |
| CHEMBL6640 | TRYPTAMINE | Ki | = | 170.0 | nM | 6.77 |
| CHEMBL416526 | BUFOTENINE | Ki | = | 259.0 | nM | 6.59 |
| CHEMBL12314 | MESULERGINE | Ki | = | 300.0 | nM | 6.52 |
| CHEMBL19264 | — | Ki | = | 1590.0 | nM | 5.80 |
| CHEMBL18331 | PIRENPERONE | Ki | = | 1700.0 | nM | 5.77 |
| CHEMBL51 | KETANSERIN | Ki | = | 1900.0 | nM | 5.72 |
| CHEMBL274866 | — | Ki | = | 1950.0 | nM | 5.71 |
| CHEMBL478 | CHLOROPHENYLPIPERAZINE | Ki | = | 2400.0 | nM | 5.62 |
| CHEMBL18772 | QUIPAZINE | Ki | = | 3300.0 | nM | 5.48 |
| CHEMBL134519 | — | Ki | - | nM | - |