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Assay Detail

CHEMBL615966

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
In vitro displacement of radioactively labeled ligand [3H]8-OH-DPAT from 5-hydroxytryptamine 1A receptor site in CHO cells
31
Total Activities
31
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Cell Type CHO
Confidence 8 — Homologous single protein target
Curated By Expert

Target

5-hydroxytryptamine receptor 1A (CHEMBL273)
Type SINGLE PROTEIN
Organism Rattus norvegicus

Publication

C-9 and N-substituted analogs of cis-(3aR)-(-)-2,3,3a,4,5,9b-hexahydro-3- propyl-1H-benz[e]indole-9-carboxamide: 5-HT1A receptor agonists with various degrees of metabolic stability.
Haadsma-Svensson SR, Svensson K, Duncan N, Smith MW, Lin CH.
J Med Chem (1995) 38 : 725 -734
PubMed 7861420 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
Ki 31 7.86 9.40

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL351234 1 9.40
CHEMBL56 8-OH-DPAT 1 9.30
CHEMBL349604 1 9.15
CHEMBL164195 1 9.00
CHEMBL421848 1 8.92
CHEMBL161890 1 8.82
CHEMBL349003 1 8.72
CHEMBL159625 1 8.66
CHEMBL161904 1 8.41
CHEMBL163134 1 8.33
CHEMBL354455 1 8.33
CHEMBL349502 1 8.08
CHEMBL161940 1 7.96
CHEMBL421839 1 7.92
CHEMBL441486 1 7.82
CHEMBL351857 1 7.66
CHEMBL352887 1 7.64
CHEMBL161891 1 7.62
CHEMBL423612 1 7.47
CHEMBL163135 1 7.39
CHEMBL160040 1 7.38
CHEMBL162767 1 7.35
CHEMBL162167 1 7.32
CHEMBL162227 1 7.28
CHEMBL159886 1 7.09
CHEMBL162035 1 7.08
CHEMBL350145 1 7.01
CHEMBL163258 1 6.89
CHEMBL163469 1 6.58
CHEMBL355601 1 6.57

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL351234 Ki = 0.4 nM 9.40
CHEMBL56 8-OH-DPAT Ki = 0.5 nM 9.30
CHEMBL349604 Ki = 0.7 nM 9.15
CHEMBL164195 Ki = 1.0 nM 9.00
CHEMBL421848 Ki = 1.2 nM 8.92
CHEMBL161890 Ki = 1.5 nM 8.82
CHEMBL349003 Ki = 1.9 nM 8.72
CHEMBL159625 Ki = 2.2 nM 8.66
CHEMBL161904 Ki = 3.9 nM 8.41
CHEMBL163134 Ki = 4.7 nM 8.33
CHEMBL354455 Ki = 4.7 nM 8.33
CHEMBL349502 Ki = 8.3 nM 8.08
CHEMBL161940 Ki = 11.0 nM 7.96
CHEMBL421839 Ki = 12.0 nM 7.92
CHEMBL441486 Ki = 15.0 nM 7.82
CHEMBL351857 Ki = 22.0 nM 7.66
CHEMBL352887 Ki = 23.0 nM 7.64
CHEMBL161891 Ki = 24.0 nM 7.62
CHEMBL423612 Ki = 34.0 nM 7.47
CHEMBL163135 Ki = 41.0 nM 7.39
CHEMBL160040 Ki = 42.0 nM 7.38
CHEMBL162767 Ki = 45.0 nM 7.35
CHEMBL162167 Ki = 48.0 nM 7.32
CHEMBL162227 Ki = 52.0 nM 7.28
CHEMBL159886 Ki = 82.0 nM 7.09
CHEMBL162035 Ki = 83.0 nM 7.08
CHEMBL350145 Ki = 97.0 nM 7.01
CHEMBL163258 Ki = 129.0 nM 6.89
CHEMBL163469 Ki = 266.0 nM 6.58
CHEMBL355601 Ki = 271.0 nM 6.57
CHEMBL163619 Ki = 434.0 nM 6.36