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Assay Detail

CHEMBL615967

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
In vitro ability to inhibit [3H]-8-OH-DPAT binding to 5-hydroxytryptamine 1A receptor in rat cortical membranes
16
Total Activities
16
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Confidence 8 — Homologous single protein target
Curated By Expert

Target

5-hydroxytryptamine receptor 1A (CHEMBL273)
Type SINGLE PROTEIN
Organism Rattus norvegicus

Publication

Novel derivatives of 3-(dipropylamino)chroman. Interactions with 5-HT1A and D2A receptors.
Caldirola P, Chowdhury R, Unelius L, Mohell N, Hacksell U, Johansson AM.
Bioorg Med Chem Lett (1999) 9 : 1583 -1586
PubMed 10386940 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
Ki 16 8.12 8.96

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL39847 1 8.96
CHEMBL41491 1 8.96
CHEMBL41134 1 8.96
CHEMBL41200 1 8.89
CHEMBL25924 1 8.74
CHEMBL42857 1 8.40
CHEMBL38580 1 8.24
CHEMBL38855 1 8.14
CHEMBL41759 1 7.98
CHEMBL43359 1 7.96
CHEMBL38656 1 7.79
CHEMBL41120 1 7.33
CHEMBL291251 1 7.22
CHEMBL43073 1 7.20
CHEMBL27995 1 7.08
CHEMBL38428 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL39847 Ki = 1.1 nM 8.96
CHEMBL41491 Ki = 1.1 nM 8.96
CHEMBL41134 Ki = 1.1 nM 8.96
CHEMBL41200 Ki = 1.3 nM 8.89
CHEMBL25924 Ki = 1.8 nM 8.74
CHEMBL42857 Ki = 4.0 nM 8.40
CHEMBL38580 Ki = 5.7 nM 8.24
CHEMBL38855 Ki = 7.3 nM 8.14
CHEMBL41759 Ki = 10.5 nM 7.98
CHEMBL43359 Ki = 11.0 nM 7.96
CHEMBL38656 Ki = 16.4 nM 7.79
CHEMBL41120 Ki = 47.2 nM 7.33
CHEMBL291251 Ki = 60.8 nM 7.22
CHEMBL43073 Ki = 63.8 nM 7.20
CHEMBL27995 Ki = 83.0 nM 7.08
CHEMBL38428 Ki > 3000.0 nM -