Assay Detail
Binding
CHEMBL615968
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In vitro binding affinity against 5-hydroxytryptamine 1A receptor of rat cerebral cortex using [3H]8-OH-DPAT as radioligand.
12
Total Activities
12
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Tissue | Cerebral cortex |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
Synthesis and structure-activity relationships of a new model of arylpiperazines. 2. Three-dimensional quantitative structure-activity relationships of hydantoin-phenylpiperazine derivatives with affinity for 5-HT1A and alpha 1 receptors. A comparison of CoMFA models.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 12 | 6.72 | 7.51 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL295168 | — | — | 1 | 7.51 |
| CHEMBL46471 | — | — | 1 | 7.46 |
| CHEMBL297844 | — | — | 1 | 7.24 |
| CHEMBL297887 | — | — | 1 | 7.23 |
| CHEMBL295244 | — | — | 1 | 7.11 |
| CHEMBL46470 | — | — | 1 | 7.07 |
| CHEMBL42654 | — | — | 1 | 7.00 |
| CHEMBL430567 | — | — | 1 | 6.92 |
| CHEMBL46672 | — | — | 1 | 6.35 |
| CHEMBL42881 | — | — | 1 | 6.30 |
| CHEMBL46862 | — | — | 1 | 5.22 |
| CHEMBL295527 | — | — | 1 | 5.21 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL295168 | — | Ki | = | 31.1 | nM | 7.51 |
| CHEMBL46471 | — | Ki | = | 34.9 | nM | 7.46 |
| CHEMBL297844 | — | Ki | = | 57.7 | nM | 7.24 |
| CHEMBL297887 | — | Ki | = | 58.4 | nM | 7.23 |
| CHEMBL295244 | — | Ki | = | 78.6 | nM | 7.11 |
| CHEMBL46470 | — | Ki | = | 85.3 | nM | 7.07 |
| CHEMBL42654 | — | Ki | = | 101.0 | nM | 7.00 |
| CHEMBL430567 | — | Ki | = | 120.0 | nM | 6.92 |
| CHEMBL46672 | — | Ki | = | 444.0 | nM | 6.35 |
| CHEMBL42881 | — | Ki | = | 500.0 | nM | 6.30 |
| CHEMBL46862 | — | Ki | = | 5970.0 | nM | 5.22 |
| CHEMBL295527 | — | Ki | = | 6095.0 | nM | 5.21 |