Assay Detail
Binding
CHEMBL615971
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In vitro binding affinity against 5-hydroxytryptamine 1A receptor using [3H]8-OH-DPAT
11
Total Activities
11
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
(S)- and (R)-8-(di-n-propylamino)-6,7,8,9-tetrahydro-3H-benz[e]indole-1- carbaldehyde: a new class of orally active 5-HT1A-receptor agonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 11 | 7.83 | 8.89 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL304426 | — | — | 1 | 8.89 |
| CHEMBL65274 | — | — | 1 | 8.85 |
| CHEMBL63449 | — | — | 1 | 8.70 |
| CHEMBL302172 | — | — | 1 | 8.15 |
| CHEMBL41436 | — | — | 1 | 8.08 |
| CHEMBL65196 | — | — | 1 | 7.92 |
| CHEMBL302171 | — | — | 1 | 7.85 |
| CHEMBL303339 | — | — | 1 | 7.60 |
| CHEMBL413105 | — | — | 1 | 7.18 |
| CHEMBL292274 | — | — | 1 | 6.72 |
| CHEMBL305341 | — | — | 1 | 6.24 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL304426 | — | Ki | = | 1.3 | nM | 8.89 |
| CHEMBL65274 | — | Ki | = | 1.4 | nM | 8.85 |
| CHEMBL63449 | — | Ki | = | 2.0 | nM | 8.70 |
| CHEMBL302172 | — | Ki | = | 7.0 | nM | 8.15 |
| CHEMBL41436 | — | Ki | = | 8.4 | nM | 8.08 |
| CHEMBL65196 | — | Ki | = | 12.0 | nM | 7.92 |
| CHEMBL302171 | — | Ki | = | 14.0 | nM | 7.85 |
| CHEMBL303339 | — | Ki | = | 25.0 | nM | 7.60 |
| CHEMBL413105 | — | Ki | = | 66.0 | nM | 7.18 |
| CHEMBL292274 | — | Ki | = | 190.0 | nM | 6.72 |
| CHEMBL305341 | — | Ki | = | 570.0 | nM | 6.24 |