Assay Detail
Binding
CHEMBL615976
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In vitro binding affinity for 5-hydroxytryptamine 1A receptor in rat hippocampal membranes by [125I]-labeled agonist displacement.
17
Total Activities
15
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Tissue | Hippocampus |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
Isoindol-1-one analogues of 4-(2'-methoxyphenyl)-1-[2'-[N-(2"-pyridyl)-p-iodobenzamido]ethyl]pipera zine (p-MPPI) as 5-HT1A receptor ligands.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 17 | 8.93 | 10.35 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL43327 | — | — | 1 | 10.35 |
| CHEMBL43099 | — | — | 2 | 10.16 |
| CHEMBL29027 | — | — | 1 | 9.70 |
| CHEMBL439740 | — | — | 1 | 9.47 |
| CHEMBL296081 | — | — | 1 | 9.30 |
| CHEMBL8618 | NAN-190 | — | 1 | 9.22 |
| CHEMBL295130 | — | — | 1 | 9.19 |
| CHEMBL296036 | — | — | 1 | 8.96 |
| CHEMBL296675 | — | — | 1 | 8.73 |
| CHEMBL42993 | — | — | 2 | 8.60 |
| CHEMBL295245 | — | — | 1 | 8.19 |
| CHEMBL42711 | — | — | 1 | 8.05 |
| CHEMBL290430 | — | — | 1 | 8.03 |
| CHEMBL42780 | — | — | 1 | 7.83 |
| CHEMBL43209 | — | — | 1 | 7.29 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL43327 | — | Ki | = | 0.045 | nM | 10.35 |
| CHEMBL43099 | — | Ki | = | 0.069 | nM | 10.16 |
| CHEMBL43099 | — | Ki | = | 0.069 | nM | 10.16 |
| CHEMBL29027 | — | Ki | = | 0.2 | nM | 9.70 |
| CHEMBL439740 | — | Ki | = | 0.34 | nM | 9.47 |
| CHEMBL296081 | — | Ki | = | 0.5 | nM | 9.30 |
| CHEMBL8618 | NAN-190 | Ki | = | 0.6 | nM | 9.22 |
| CHEMBL295130 | — | Ki | = | 0.65 | nM | 9.19 |
| CHEMBL296036 | — | Ki | = | 1.09 | nM | 8.96 |
| CHEMBL296675 | — | Ki | = | 1.85 | nM | 8.73 |
| CHEMBL42993 | — | Ki | = | 2.54 | nM | 8.60 |
| CHEMBL42993 | — | Ki | = | 2.54 | nM | 8.60 |
| CHEMBL295245 | — | Ki | = | 6.5 | nM | 8.19 |
| CHEMBL42711 | — | Ki | = | 8.9 | nM | 8.05 |
| CHEMBL290430 | — | Ki | = | 9.3 | nM | 8.03 |
| CHEMBL42780 | — | Ki | = | 14.9 | nM | 7.83 |
| CHEMBL43209 | — | Ki | = | 51.7 | nM | 7.29 |