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Assay Detail

CHEMBL616052

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Displacement of [3H]8-OH-DPAT from rat striata 5-hydroxytryptamine 1A receptor
13
Total Activities
13
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Rattus norvegicus
Confidence 9 — Direct single protein target
Curated By Expert

Target

5-hydroxytryptamine receptor 1A (CHEMBL273)
Type SINGLE PROTEIN
Organism Rattus norvegicus

Publication

N-[[1-(2-phenylethyl)pyrrolidin-2-yl]methyl]cyclohexanecarboxamides as selective 5-HT1A receptor agonists.
Fujio M, Togo Y, Tomozane H, Kuroita T, Morio Y, Katayama J, Matsumoto Y.
Bioorg Med Chem Lett (2000) 10 : 509 -512
PubMed 10743959 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
Ki 13 7.74 9.33

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL56 8-OH-DPAT 1 9.33
CHEMBL82884 1 9.31
CHEMBL356304 1 8.37
CHEMBL147279 1 8.34
CHEMBL281363 1 8.00
CHEMBL148352 1 7.68
CHEMBL356945 1 7.62
CHEMBL283528 1 7.47
CHEMBL279937 1 7.46
CHEMBL149723 1 7.00
CHEMBL148249 1 6.96
CHEMBL82652 1 6.72
CHEMBL279729 1 6.37

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL56 8-OH-DPAT Ki = 0.47 nM 9.33
CHEMBL82884 Ki = 0.49 nM 9.31
CHEMBL356304 Ki = 4.3 nM 8.37
CHEMBL147279 Ki = 4.6 nM 8.34
CHEMBL281363 Ki = 10.0 nM 8.00
CHEMBL148352 Ki = 21.0 nM 7.68
CHEMBL356945 Ki = 24.0 nM 7.62
CHEMBL283528 Ki = 34.0 nM 7.47
CHEMBL279937 Ki = 35.0 nM 7.46
CHEMBL149723 Ki = 100.0 nM 7.00
CHEMBL148249 Ki = 110.0 nM 6.96
CHEMBL82652 Ki = 190.0 nM 6.72
CHEMBL279729 Ki = 430.0 nM 6.37