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Assay Detail

CHEMBL616053

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Binding affinity in radioreceptor binding assay by using [3H]5-HT radioligand against 5-hydroxytryptamine 1A receptor
1
Total Activities
1
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Confidence 8 — Homologous single protein target
Curated By Autocuration

Target

5-hydroxytryptamine receptor 1A (CHEMBL273)
Type SINGLE PROTEIN
Organism Rattus norvegicus

Publication

Activity of aromatic substituted phenylpiperazines lacking affinity for dopamine binding sites in a preclinical test of antipsychotic efficacy.
Martin GE, Elgin RJ, Mathiasen JR, Davis CB, Kesslick JM, Baldy WJ, Shank RP, DiStefano DL, Fedde CL, Scott MK.
J Med Chem (1989) 32 : 1052 -1056
PubMed 2565400 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
Ki 1 7.09 7.09

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL274866 1 7.09

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL274866 Ki = 80.6 nM 7.09