Assay Detail
Binding
CHEMBL616054
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Binding affinity towards 5-HT 1A receptor in rat cerebral cortex membranes using [3H]8-OH-DPAT as radioligand
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Tissue | Cerebral cortex |
| Subcellular | Membrane |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Design and synthesis of S-(-)-2-[[4-(napht-1-yl)piperazin-1-yl]methyl]-1,4-dioxoperhydropyrrolo[1,2-a]pyrazine (CSP-2503) using computational simulation. A 5-HT1A receptor agonist.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 8 | 8.22 | 8.62 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL33150 | — | — | 1 | 8.62 |
| CHEMBL33258 | — | — | 1 | 8.39 |
| CHEMBL285066 | — | — | 1 | 8.39 |
| CHEMBL445055 | — | — | 1 | 8.25 |
| CHEMBL2113339 | — | — | 1 | 8.21 |
| CHEMBL34287 | — | — | 1 | 8.03 |
| CHEMBL430914 | — | — | 1 | 7.98 |
| CHEMBL2113340 | — | — | 1 | 7.91 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL33150 | — | Ki | = | 2.4 | nM | 8.62 |
| CHEMBL33258 | — | Ki | = | 4.1 | nM | 8.39 |
| CHEMBL285066 | — | Ki | = | 4.1 | nM | 8.39 |
| CHEMBL445055 | — | Ki | = | 5.6 | nM | 8.25 |
| CHEMBL2113339 | — | Ki | = | 6.1 | nM | 8.21 |
| CHEMBL34287 | — | Ki | = | 9.3 | nM | 8.03 |
| CHEMBL430914 | — | Ki | = | 10.4 | nM | 7.98 |
| CHEMBL2113340 | — | Ki | = | 12.3 | nM | 7.91 |