Assay Detail
Binding
CHEMBL616061
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Binding affinity towards 5-hydroxytryptamine 1A receptor in the rat brain (hippocampus) using [3H]8-OH-DPAT
10
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Tissue | Hippocampus |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
8-[4-[2-(1,2,3,4-Tetrahydroisoquinolinyl]butyl-8-azaspiro[4.5]decane-7,9-dione: a new 5-HT1A receptor ligand with the same activity profile as buspirone.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 10 | 7.15 | 9.22 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL8618 | NAN-190 | — | 1 | 9.22 |
| CHEMBL14161 | — | — | 1 | 8.30 |
| CHEMBL279841 | — | — | 1 | 8.19 |
| CHEMBL13647 | BMY-7378 | — | 1 | 8.09 |
| CHEMBL49 | BUSPIRONE | 4.0 | 1 | 7.91 |
| CHEMBL273241 | — | — | 1 | 6.85 |
| CHEMBL14209 | — | — | 1 | 5.88 |
| CHEMBL14308 | — | — | 1 | 5.54 |
| CHEMBL14149 | — | — | 1 | 4.38 |
| CHEMBL14346 | 1,2,3,4-TETRAHYDROISOQUINOLINE | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL8618 | NAN-190 | Ki | = | 0.6 | nM | 9.22 |
| CHEMBL14161 | — | Ki | = | 5.0 | nM | 8.30 |
| CHEMBL279841 | — | Ki | = | 6.4 | nM | 8.19 |
| CHEMBL13647 | BMY-7378 | Ki | = | 8.2 | nM | 8.09 |
| CHEMBL49 | BUSPIRONE | Ki | = | 12.3 | nM | 7.91 |
| CHEMBL273241 | — | Ki | = | 140.0 | nM | 6.85 |
| CHEMBL14209 | — | Ki | = | 1330.0 | nM | 5.88 |
| CHEMBL14308 | — | Ki | = | 2920.0 | nM | 5.54 |
| CHEMBL14149 | — | Ki | = | 41300.0 | nM | 4.38 |
| CHEMBL14346 | 1,2,3,4-TETRAHYDROISOQUINOLINE | Ki | > | 50000.0 | nM | - |