Assay Detail
Binding
CHEMBL616062
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Binding affinity towards 5-hydroxytryptamine 1A receptor of rat hippocampus using [3H]-8-hydroxy-2-(di-n-propylamine) tetralin (8-OH-DPAT) as a radioligand
18
Total Activities
18
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Tissue | Hippocampus |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
Analogues of the 5-HT1A serotonin antagonist 1-(2-methoxyphenyl)-4-[4-(2-phthalimido)butyl]piperazine with reduced alpha 1-adrenergic affinity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 18 | 8.31 | 9.40 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL26533 | — | — | 1 | 9.40 |
| CHEMBL8618 | NAN-190 | — | 1 | 9.22 |
| CHEMBL410826 | — | — | 1 | 9.15 |
| CHEMBL21008 | — | — | 1 | 9.00 |
| CHEMBL26587 | — | — | 1 | 9.00 |
| CHEMBL27996 | — | — | 1 | 8.70 |
| CHEMBL26188 | — | — | 1 | 8.70 |
| CHEMBL24515 | — | — | 1 | 8.44 |
| CHEMBL26189 | — | — | 1 | 8.40 |
| CHEMBL27254 | — | — | 1 | 8.40 |
| CHEMBL282902 | — | — | 1 | 8.36 |
| CHEMBL27377 | — | — | 1 | 8.27 |
| CHEMBL287186 | — | — | 1 | 8.20 |
| CHEMBL27098 | — | — | 1 | 8.12 |
| CHEMBL26539 | — | — | 1 | 7.92 |
| CHEMBL26306 | — | — | 1 | 7.66 |
| CHEMBL316090 | — | — | 1 | 6.67 |
| CHEMBL26030 | — | — | 1 | 6.00 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL26533 | — | Ki | = | 0.4 | nM | 9.40 |
| CHEMBL8618 | NAN-190 | Ki | = | 0.6 | nM | 9.22 |
| CHEMBL410826 | — | Ki | = | 0.7 | nM | 9.15 |
| CHEMBL21008 | — | Ki | = | 1.0 | nM | 9.00 |
| CHEMBL26587 | — | Ki | = | 1.0 | nM | 9.00 |
| CHEMBL27996 | — | Ki | = | 2.0 | nM | 8.70 |
| CHEMBL26188 | — | Ki | = | 2.0 | nM | 8.70 |
| CHEMBL24515 | — | Ki | = | 3.6 | nM | 8.44 |
| CHEMBL26189 | — | Ki | = | 4.0 | nM | 8.40 |
| CHEMBL27254 | — | Ki | = | 4.0 | nM | 8.40 |
| CHEMBL282902 | — | Ki | = | 4.4 | nM | 8.36 |
| CHEMBL27377 | — | Ki | = | 5.4 | nM | 8.27 |
| CHEMBL287186 | — | Ki | = | 6.3 | nM | 8.20 |
| CHEMBL27098 | — | Ki | = | 7.5 | nM | 8.12 |
| CHEMBL26539 | — | Ki | = | 12.0 | nM | 7.92 |
| CHEMBL26306 | — | Ki | = | 22.0 | nM | 7.66 |
| CHEMBL316090 | — | Ki | = | 213.0 | nM | 6.67 |
| CHEMBL26030 | — | Ki | = | 1000.0 | nM | 6.00 |