Assay Detail
Binding
CHEMBL616067
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Binding affinity towards rat hippocampal 5-hydroxytryptamine 1A receptor using [3H]8-OH-DPAT as radioligand
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Tissue | Hippocampus |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Dihydrobenzofuran analogues of hallucinogens. 3. Models of 4-substituted (2,5-dimethoxyphenyl)alkylamine derivatives with rigidified methoxy groups.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 5 | 8.30 | 9.10 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL101189 | — | — | 1 | 9.10 |
| CHEMBL101008 | — | — | 1 | 8.37 |
| CHEMBL100626 | — | — | 1 | 8.28 |
| CHEMBL6607 | BROLAMFETAMINE | 2.0 | 1 | 8.21 |
| CHEMBL99846 | — | — | 1 | 7.54 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL101189 | — | Ki | = | 0.8 | nM | 9.10 |
| CHEMBL101008 | — | Ki | = | 4.3 | nM | 8.37 |
| CHEMBL100626 | — | Ki | = | 5.2 | nM | 8.28 |
| CHEMBL6607 | BROLAMFETAMINE | Ki | = | 6.1 | nM | 8.21 |
| CHEMBL99846 | — | Ki | = | 29.0 | nM | 7.54 |