Assay Detail
Binding
CHEMBL616070
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Binding was determined on 5-hydroxytryptamine 1A receptor in rat hippocampal membranes
31
Total Activities
24
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Tissue | Hippocampus |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
trans-4-[4-(Methoxyphenyl)cyclohexyl]-1-arylpiperazines: a new class of potent and selective 5-HT(1A) receptor ligands as conformationally constrained analogues of 4-[3-(5-methoxy-1,2,3,4-tetrahydronaphthalen-1-yl)propyl]-1-arylpiperazines.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 31 | 8.25 | 10.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2112779 | — | — | 2 | 10.70 |
| CHEMBL2112780 | — | — | 2 | 10.59 |
| CHEMBL2112778 | — | — | 2 | 10.55 |
| CHEMBL2112771 | — | — | 2 | 10.34 |
| CHEMBL423181 | — | — | 1 | 9.80 |
| CHEMBL138109 | — | — | 1 | 9.72 |
| CHEMBL2112773 | — | — | 2 | 9.70 |
| CHEMBL2112776 | — | — | 2 | 9.66 |
| CHEMBL140406 | — | — | 1 | 9.51 |
| CHEMBL139505 | — | — | 1 | 9.42 |
| CHEMBL444590 | — | — | 1 | 9.32 |
| CHEMBL344432 | — | — | 1 | 9.27 |
| CHEMBL136563 | — | — | 1 | 9.15 |
| CHEMBL56 | 8-OH-DPAT | — | 1 | 8.68 |
| CHEMBL138892 | — | — | 1 | 8.15 |
| CHEMBL138289 | — | — | 1 | 7.82 |
| CHEMBL2112774 | — | — | 2 | 7.77 |
| CHEMBL344146 | — | — | 1 | 7.64 |
| CHEMBL49 | BUSPIRONE | 4.0 | 1 | 7.50 |
| CHEMBL139146 | — | — | 1 | 7.41 |
| CHEMBL138899 | — | — | 1 | 7.23 |
| CHEMBL139848 | — | — | 1 | 6.59 |
| CHEMBL140287 | — | — | 1 | 6.27 |
| CHEMBL138900 | — | — | 1 | 6.17 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2112779 | — | Ki | = | 0.02 | nM | 10.70 |
| CHEMBL2112780 | — | Ki | = | 0.026 | nM | 10.59 |
| CHEMBL2112778 | — | Ki | = | 0.028 | nM | 10.55 |
| CHEMBL2112771 | — | Ki | = | 0.046 | nM | 10.34 |
| CHEMBL423181 | — | Ki | = | 0.16 | nM | 9.80 |
| CHEMBL138109 | — | Ki | = | 0.19 | nM | 9.72 |
| CHEMBL2112773 | — | Ki | = | 0.2 | nM | 9.70 |
| CHEMBL2112776 | — | Ki | = | 0.22 | nM | 9.66 |
| CHEMBL140406 | — | Ki | = | 0.31 | nM | 9.51 |
| CHEMBL139505 | — | Ki | = | 0.38 | nM | 9.42 |
| CHEMBL444590 | — | Ki | = | 0.48 | nM | 9.32 |
| CHEMBL344432 | — | Ki | = | 0.54 | nM | 9.27 |
| CHEMBL136563 | — | Ki | = | 0.71 | nM | 9.15 |
| CHEMBL56 | 8-OH-DPAT | Ki | = | 2.1 | nM | 8.68 |
| CHEMBL138892 | — | Ki | = | 7.1 | nM | 8.15 |
| CHEMBL138289 | — | Ki | = | 15.0 | nM | 7.82 |
| CHEMBL2112774 | — | Ki | = | 17.0 | nM | 7.77 |
| CHEMBL344146 | — | Ki | = | 23.0 | nM | 7.64 |
| CHEMBL49 | BUSPIRONE | Ki | = | 32.0 | nM | 7.50 |
| CHEMBL139146 | — | Ki | = | 39.0 | nM | 7.41 |
| CHEMBL138899 | — | Ki | = | 59.0 | nM | 7.23 |
| CHEMBL2112776 | — | Ki | = | 74.0 | nM | 7.13 |
| CHEMBL2112779 | — | Ki | = | 79.6 | nM | 7.10 |
| CHEMBL2112771 | — | Ki | = | 94.0 | nM | 7.03 |
| CHEMBL2112780 | — | Ki | = | 183.0 | nM | 6.74 |
| CHEMBL139848 | — | Ki | = | 257.0 | nM | 6.59 |
| CHEMBL2112774 | — | Ki | = | 373.0 | nM | 6.43 |
| CHEMBL2112773 | — | Ki | = | 480.0 | nM | 6.32 |
| CHEMBL140287 | — | Ki | = | 536.0 | nM | 6.27 |
| CHEMBL138900 | — | Ki | = | 676.0 | nM | 6.17 |
| CHEMBL2112778 | — | Ki | = | 815.0 | nM | 6.09 |