Assay Detail
Binding
CHEMBL616072
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Binding affinity against 5-hydroxytryptamine 1A receptor on rat hippocampus using [3H]8-OH-DPAT as radioligand.
34
Total Activities
32
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Tissue | Hippocampus |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
Synthesis and pharmacological characterization of novel 6-fluorochroman derivatives as potential 5-HT1A receptor antagonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 34 | 8.15 | 9.80 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL419147 | — | — | 1 | 9.80 |
| CHEMBL96578 | — | — | 1 | 9.73 |
| CHEMBL25213 | — | — | 1 | 9.66 |
| CHEMBL96222 | — | — | 1 | 9.57 |
| CHEMBL96714 | — | — | 3 | 9.51 |
| CHEMBL96279 | — | — | 1 | 9.36 |
| CHEMBL96517 | — | — | 1 | 8.63 |
| CHEMBL93503 | — | — | 1 | 8.59 |
| CHEMBL94317 | — | — | 1 | 8.57 |
| CHEMBL93030 | — | — | 1 | 8.51 |
| CHEMBL96435 | — | — | 1 | 8.39 |
| CHEMBL318417 | — | — | 1 | 8.38 |
| CHEMBL95044 | — | — | 1 | 8.13 |
| CHEMBL96546 | — | — | 1 | 8.05 |
| CHEMBL92651 | — | — | 1 | 8.02 |
| CHEMBL96903 | — | — | 1 | 7.96 |
| CHEMBL329675 | — | — | 1 | 7.75 |
| CHEMBL318418 | — | — | 1 | 7.74 |
| CHEMBL96266 | — | — | 1 | 7.74 |
| CHEMBL96265 | — | — | 1 | 7.72 |
| CHEMBL313420 | — | — | 1 | 7.71 |
| CHEMBL96901 | — | — | 1 | 7.62 |
| CHEMBL96858 | — | — | 1 | 7.56 |
| CHEMBL94957 | — | — | 1 | 7.55 |
| CHEMBL330714 | — | — | 1 | 7.38 |
| CHEMBL94428 | — | — | 1 | 7.36 |
| CHEMBL92668 | — | — | 1 | 7.31 |
| CHEMBL95135 | — | — | 1 | 7.28 |
| CHEMBL319575 | — | — | 1 | 7.25 |
| CHEMBL316593 | — | — | 1 | 7.16 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL419147 | — | Ki | = | 0.159 | nM | 9.80 |
| CHEMBL96578 | — | Ki | = | 0.188 | nM | 9.73 |
| CHEMBL25213 | — | Ki | = | 0.221 | nM | 9.66 |
| CHEMBL96222 | — | Ki | = | 0.27 | nM | 9.57 |
| CHEMBL96714 | — | Ki | = | 0.31 | nM | 9.51 |
| CHEMBL96279 | — | Ki | = | 0.435 | nM | 9.36 |
| CHEMBL96714 | — | Ki | = | 0.716 | nM | 9.14 |
| CHEMBL96714 | — | Ki | = | 2.1 | nM | 8.68 |
| CHEMBL96517 | — | Ki | = | 2.34 | nM | 8.63 |
| CHEMBL93503 | — | Ki | = | 2.6 | nM | 8.59 |
| CHEMBL94317 | — | Ki | = | 2.67 | nM | 8.57 |
| CHEMBL93030 | — | Ki | = | 3.07 | nM | 8.51 |
| CHEMBL96435 | — | Ki | = | 4.04 | nM | 8.39 |
| CHEMBL318417 | — | Ki | = | 4.19 | nM | 8.38 |
| CHEMBL95044 | — | Ki | = | 7.33 | nM | 8.13 |
| CHEMBL96546 | — | Ki | = | 8.99 | nM | 8.05 |
| CHEMBL92651 | — | Ki | = | 9.53 | nM | 8.02 |
| CHEMBL96903 | — | Ki | = | 11.0 | nM | 7.96 |
| CHEMBL329675 | — | Ki | = | 18.0 | nM | 7.75 |
| CHEMBL96266 | — | Ki | = | 18.4 | nM | 7.74 |
| CHEMBL318418 | — | Ki | = | 18.3 | nM | 7.74 |
| CHEMBL96265 | — | Ki | = | 19.0 | nM | 7.72 |
| CHEMBL313420 | — | Ki | = | 19.3 | nM | 7.71 |
| CHEMBL96901 | — | Ki | = | 24.0 | nM | 7.62 |
| CHEMBL96858 | — | Ki | = | 27.7 | nM | 7.56 |
| CHEMBL94957 | — | Ki | = | 28.3 | nM | 7.55 |
| CHEMBL330714 | — | Ki | = | 41.8 | nM | 7.38 |
| CHEMBL94428 | — | Ki | = | 43.4 | nM | 7.36 |
| CHEMBL92668 | — | Ki | = | 48.8 | nM | 7.31 |
| CHEMBL95135 | — | Ki | = | 52.7 | nM | 7.28 |
| CHEMBL319575 | — | Ki | = | 55.8 | nM | 7.25 |
| CHEMBL316593 | — | Ki | = | 69.0 | nM | 7.16 |
| CHEMBL94303 | — | Ki | = | 77.0 | nM | 7.11 |
| CHEMBL317532 | — | Ki | = | 680.0 | nM | 6.17 |