Assay Detail
Binding
CHEMBL616078
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Binding affinity for 5-hydroxytryptamine 1A receptor measured by displacing [3H]8-OH-DPAT from rat cortical membranes
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Pyrimido[5,4-b]indole derivatives. 1. A new class of potent and selective alpha 1 adrenoceptor ligands.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 8 | 7.30 | 8.82 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL54716 | — | — | 1 | 8.82 |
| CHEMBL301707 | — | — | 1 | 7.30 |
| CHEMBL9666 | — | — | 1 | 6.55 |
| CHEMBL55528 | — | — | 1 | 6.51 |
| CHEMBL52473 | — | — | 1 | - |
| CHEMBL57163 | — | — | 1 | - |
| CHEMBL51963 | — | — | 1 | - |
| CHEMBL55338 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL54716 | — | Ki | = | 1.5 | nM | 8.82 |
| CHEMBL301707 | — | Ki | = | 50.0 | nM | 7.30 |
| CHEMBL9666 | — | Ki | = | 281.0 | nM | 6.55 |
| CHEMBL55528 | — | Ki | = | 308.0 | nM | 6.51 |
| CHEMBL52473 | — | Ki | > | 100000.0 | nM | - |
| CHEMBL57163 | — | Ki | > | 100000.0 | nM | - |
| CHEMBL51963 | — | Ki | > | 100000.0 | nM | - |
| CHEMBL55338 | — | Ki | > | 100000.0 | nM | - |