Assay Detail
Binding
CHEMBL616080
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Binding affinity against [3H]8-OH-DPAT binding to 5-hydroxytryptamine 1A receptor expressed in CHO-K1 cells
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Cell Type | CHO-K1 |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Regioselective synthesis of 3-aryl substituted pyrrolidines via palladium catalyzed arylation: pharmacological evaluation for central dopaminergic and serotonergic activity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 8 | 6.59 | 7.14 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL82485 | — | — | 1 | 7.14 |
| CHEMBL311972 | — | — | 1 | 7.02 |
| CHEMBL3706603 | — | — | 1 | 6.76 |
| CHEMBL81675 | — | — | 1 | 6.70 |
| CHEMBL310607 | — | — | 1 | 6.46 |
| CHEMBL82541 | — | — | 1 | 6.34 |
| CHEMBL79812 | — | — | 1 | 6.19 |
| CHEMBL310745 | — | — | 1 | 6.09 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL82485 | — | Ki | = | 73.0 | nM | 7.14 |
| CHEMBL311972 | — | Ki | = | 95.0 | nM | 7.02 |
| CHEMBL3706603 | — | Ki | = | 174.0 | nM | 6.76 |
| CHEMBL81675 | — | Ki | = | 201.0 | nM | 6.70 |
| CHEMBL310607 | — | Ki | = | 351.0 | nM | 6.46 |
| CHEMBL82541 | — | Ki | = | 453.0 | nM | 6.34 |
| CHEMBL79812 | — | Ki | = | 652.0 | nM | 6.19 |
| CHEMBL310745 | — | Ki | = | 807.0 | nM | 6.09 |