Assay Detail
Binding
CHEMBL616086
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Binding affinity towards 5-hydroxytryptamine 1A receptor in rat cerebral cortex using [3H]-8-OH-DPAT
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Tissue | Cerebral cortex |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
alpha1-Adrenoceptor antagonists. 5. Pyridazinone-arylpiperazines. Probing the influence on affinity and selectivity of both ortho-alkoxy groups at the arylpiperazine moiety and cyclic substituents at the pyridazinone nucleus.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 7 | 9.52 | 9.80 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL48163 | — | — | 1 | 9.80 |
| CHEMBL300094 | — | — | 1 | 9.66 |
| CHEMBL47792 | — | — | 1 | 9.10 |
| CHEMBL45726 | — | — | 1 | - |
| CHEMBL49152 | — | — | 1 | - |
| CHEMBL46172 | — | — | 1 | - |
| CHEMBL300092 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL48163 | — | Ki | = | 0.16 | nM | 9.80 |
| CHEMBL300094 | — | Ki | = | 0.22 | nM | 9.66 |
| CHEMBL47792 | — | Ki | = | 0.8 | nM | 9.10 |
| CHEMBL45726 | — | Ki | - | nM | - | |
| CHEMBL49152 | — | Ki | - | nM | - | |
| CHEMBL46172 | — | Ki | - | nM | - | |
| CHEMBL300092 | — | Ki | - | nM | - |