Assay Detail
Binding
CHEMBL616088
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Binding affinity was determined against 5-hydroxytryptamine 1A receptor using [3H]WB-4101
48
Total Activities
48
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
Piperazinylalkyl heterocycles as potential antipsychotic agents.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 48 | 8.00 | 10.15 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1161097 | — | — | 1 | 10.15 |
| CHEMBL1161065 | — | — | 1 | 9.60 |
| CHEMBL544373 | — | — | 1 | 9.39 |
| CHEMBL544371 | — | — | 1 | 9.20 |
| CHEMBL1161068 | — | — | 1 | 9.08 |
| CHEMBL1161055 | — | — | 1 | 8.85 |
| CHEMBL1161061 | — | — | 1 | 8.82 |
| CHEMBL10085 | MAZAPERTINE | 2.0 | 1 | 8.77 |
| CHEMBL133765 | — | — | 1 | 8.72 |
| CHEMBL1161063 | — | — | 1 | 8.72 |
| CHEMBL1161052 | — | — | 1 | 8.64 |
| CHEMBL542483 | — | — | 1 | 8.60 |
| CHEMBL552830 | — | — | 1 | 8.51 |
| CHEMBL538280 | — | — | 1 | 8.49 |
| CHEMBL428175 | RWJ-25730 | — | 1 | 8.38 |
| CHEMBL1161071 | — | — | 1 | 8.38 |
| CHEMBL1161064 | — | — | 1 | 8.35 |
| CHEMBL1161059 | — | — | 1 | 8.34 |
| CHEMBL1161074 | — | — | 1 | 8.33 |
| CHEMBL49 | BUSPIRONE | 4.0 | 1 | 8.30 |
| CHEMBL1161067 | — | — | 1 | 8.24 |
| CHEMBL1161069 | — | — | 1 | 8.15 |
| CHEMBL1161073 | — | — | 1 | 8.03 |
| CHEMBL124285 | — | — | 1 | 8.00 |
| CHEMBL1161045 | — | — | 1 | 7.96 |
| CHEMBL1161075 | — | — | 1 | 7.96 |
| CHEMBL1161051 | — | — | 1 | 7.92 |
| CHEMBL1161094 | — | — | 1 | 7.92 |
| CHEMBL1161044 | — | — | 1 | 7.80 |
| CHEMBL1161057 | — | — | 1 | 7.75 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1161097 | — | Ki | = | 0.07 | nM | 10.15 |
| CHEMBL1161065 | — | Ki | = | 0.25 | nM | 9.60 |
| CHEMBL544373 | — | Ki | = | 0.41 | nM | 9.39 |
| CHEMBL544371 | — | Ki | = | 0.63 | nM | 9.20 |
| CHEMBL1161068 | — | Ki | = | 0.84 | nM | 9.08 |
| CHEMBL1161055 | — | Ki | = | 1.4 | nM | 8.85 |
| CHEMBL1161061 | — | Ki | = | 1.5 | nM | 8.82 |
| CHEMBL10085 | MAZAPERTINE | Ki | = | 1.7 | nM | 8.77 |
| CHEMBL133765 | — | Ki | = | 1.9 | nM | 8.72 |
| CHEMBL1161063 | — | Ki | = | 1.9 | nM | 8.72 |
| CHEMBL1161052 | — | Ki | = | 2.3 | nM | 8.64 |
| CHEMBL542483 | — | Ki | = | 2.5 | nM | 8.60 |
| CHEMBL552830 | — | Ki | = | 3.1 | nM | 8.51 |
| CHEMBL538280 | — | Ki | = | 3.2 | nM | 8.49 |
| CHEMBL1161071 | — | Ki | = | 4.2 | nM | 8.38 |
| CHEMBL428175 | RWJ-25730 | Ki | = | 4.2 | nM | 8.38 |
| CHEMBL1161064 | — | Ki | = | 4.5 | nM | 8.35 |
| CHEMBL1161059 | — | Ki | = | 4.6 | nM | 8.34 |
| CHEMBL1161074 | — | Ki | = | 4.7 | nM | 8.33 |
| CHEMBL49 | BUSPIRONE | Ki | = | 5.0 | nM | 8.30 |
| CHEMBL1161067 | — | Ki | = | 5.7 | nM | 8.24 |
| CHEMBL1161069 | — | Ki | = | 7.1 | nM | 8.15 |
| CHEMBL1161073 | — | Ki | = | 9.4 | nM | 8.03 |
| CHEMBL124285 | — | Ki | = | 10.0 | nM | 8.00 |
| CHEMBL1161045 | — | Ki | = | 11.0 | nM | 7.96 |
| CHEMBL1161075 | — | Ki | = | 11.0 | nM | 7.96 |
| CHEMBL1161051 | — | Ki | = | 12.0 | nM | 7.92 |
| CHEMBL1161094 | — | Ki | = | 12.0 | nM | 7.92 |
| CHEMBL1161044 | — | Ki | = | 16.0 | nM | 7.80 |
| CHEMBL1161057 | — | Ki | = | 18.0 | nM | 7.75 |
| CHEMBL1161072 | — | Ki | = | 21.0 | nM | 7.68 |
| CHEMBL1161046 | — | Ki | = | 25.0 | nM | 7.60 |
| CHEMBL1161095 | — | Ki | = | 27.0 | nM | 7.57 |
| CHEMBL1161060 | — | Ki | = | 29.0 | nM | 7.54 |
| CHEMBL1161043 | — | Ki | = | 32.0 | nM | 7.50 |
| CHEMBL1161070 | — | Ki | = | 38.0 | nM | 7.42 |
| CHEMBL1161066 | — | Ki | = | 39.0 | nM | 7.41 |
| CHEMBL42 | CLOZAPINE | Ki | = | 39.0 | nM | 7.41 |
| CHEMBL1161056 | — | Ki | = | 39.0 | nM | 7.41 |
| CHEMBL1161049 | — | Ki | = | 48.0 | nM | 7.32 |
| CHEMBL1161054 | — | Ki | = | 51.0 | nM | 7.29 |
| CHEMBL1161048 | — | Ki | = | 57.0 | nM | 7.24 |
| CHEMBL538529 | — | Ki | = | 94.0 | nM | 7.03 |
| CHEMBL133880 | — | Ki | = | 120.0 | nM | 6.92 |
| CHEMBL1161050 | — | Ki | = | 248.0 | nM | 6.61 |
| CHEMBL54 | HALOPERIDOL | Ki | = | 401.0 | nM | 6.40 |
| CHEMBL553555 | — | Ki | = | 829.0 | nM | 6.08 |
| CHEMBL334889 | — | Ki | = | 1000.0 | nM | 6.00 |