Assay Detail
Binding
CHEMBL616090
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Binding affinity was measured against 5-hydroxytryptamine 1A receptor by displacement of [3H]8-OH-DPAT by lysergic acid amides
10
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Stereoselective LSD-like activity in a series of d-lysergic acid amides of (R)- and (S)-2-aminoalkanes.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 10 | 8.55 | 9.49 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL422732 | — | — | 1 | 9.49 |
| CHEMBL369829 | — | — | 1 | 9.22 |
| CHEMBL66335 | — | — | 1 | 8.70 |
| CHEMBL424777 | — | — | 1 | 8.68 |
| CHEMBL176343 | — | — | 1 | 8.48 |
| CHEMBL177034 | — | — | 1 | 8.34 |
| CHEMBL172369 | — | — | 1 | 8.31 |
| CHEMBL263881 | LYSERGIDE | 2.0 | 1 | 8.29 |
| CHEMBL367921 | — | — | 1 | 8.10 |
| CHEMBL172947 | — | — | 1 | 7.85 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL422732 | — | Ki | = | 0.32 | nM | 9.49 |
| CHEMBL369829 | — | Ki | = | 0.6 | nM | 9.22 |
| CHEMBL66335 | — | Ki | = | 2.0 | nM | 8.70 |
| CHEMBL424777 | — | Ki | = | 2.1 | nM | 8.68 |
| CHEMBL176343 | — | Ki | = | 3.3 | nM | 8.48 |
| CHEMBL177034 | — | Ki | = | 4.6 | nM | 8.34 |
| CHEMBL172369 | — | Ki | = | 4.9 | nM | 8.31 |
| CHEMBL263881 | LYSERGIDE | Ki | = | 5.1 | nM | 8.29 |
| CHEMBL367921 | — | Ki | = | 8.0 | nM | 8.10 |
| CHEMBL172947 | — | Ki | = | 14.0 | nM | 7.85 |