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Assay Detail

CHEMBL616092

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Binding affinity of the compound towards 5-hydroxytryptamine 1A receptor sites, in rat striatum membranes using [3H]- sandoz 205-501 as radioligand
1
Total Activities
1
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Tissue Striatum
Subcellular Membrane
Confidence 8 — Homologous single protein target
Curated By Autocuration

Target

5-hydroxytryptamine receptor 1A (CHEMBL273)
Type SINGLE PROTEIN
Organism Rattus norvegicus

Publication

(S)-5-fluoro-8-hydroxy-2-(dipropylamino)tetralin: a putative 5-HT1A-receptor antagonist.
Hillver SE, Björk L, Li YL, Svensson B, Ross S, Andén NE, Hacksell U.
J Med Chem (1990) 33 : 1541 -1544
PubMed 2140413 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
Ki 1 6.14 6.14

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL41716 1 6.14

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL41716 Ki = 730.0 nM 6.14