Assay Detail
Binding
CHEMBL616095
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Compound is evaluated for binding affinity towards 5-hydroxytryptamine 1A receptor using [3H]-8-OH- -DPAT in rat brain cortex
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Tissue | Brain |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Studies on quinazolines and 1,2,4-benzothiadiazine 1,1-dioxides. 8.1, 2 synthesis and pharmacological evaluation of tricyclic fused quinazolines and 1,2,4-benzothiadiazine 1,1-dioxides as potential alpha1-adrenoceptor antagonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 5 | 6.65 | 7.80 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL51433 | — | — | 1 | 7.80 |
| CHEMBL106737 | — | — | 1 | 6.81 |
| CHEMBL302021 | — | — | 1 | 6.62 |
| CHEMBL1744044 | — | — | 1 | 6.62 |
| CHEMBL107084 | — | — | 1 | 5.40 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL51433 | — | Ki | = | 16.0 | nM | 7.80 |
| CHEMBL106737 | — | Ki | = | 155.0 | nM | 6.81 |
| CHEMBL302021 | — | Ki | = | 238.0 | nM | 6.62 |
| CHEMBL1744044 | — | Ki | = | 237.0 | nM | 6.62 |
| CHEMBL107084 | — | Ki | = | 4000.0 | nM | 5.40 |