Assay Detail
Binding
CHEMBL616103
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Compound was evaluated for its ability to displace [3H]8-OH-DPAT from serotonergic 5-hydroxytryptamine 1A receptor
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
N-(2-pyrrolidinylmethyl)benzoxazine-8-carboxamides exhibiting high affinities for All of D2, 5-HT1 A, and 5-HT2 receptors
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 8 | 6.40 | 7.47 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL283528 | — | — | 1 | 7.47 |
| CHEMBL22465 | — | — | 1 | 6.77 |
| CHEMBL284027 | — | — | 1 | 6.55 |
| CHEMBL279729 | — | — | 1 | 6.37 |
| CHEMBL280879 | — | — | 1 | 6.35 |
| CHEMBL22857 | — | — | 1 | 5.92 |
| CHEMBL278762 | — | — | 1 | 5.35 |
| CHEMBL22777 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL283528 | — | Ki | = | 34.0 | nM | 7.47 |
| CHEMBL22465 | — | Ki | = | 170.0 | nM | 6.77 |
| CHEMBL284027 | — | Ki | = | 280.0 | nM | 6.55 |
| CHEMBL279729 | — | Ki | = | 430.0 | nM | 6.37 |
| CHEMBL280879 | — | Ki | = | 450.0 | nM | 6.35 |
| CHEMBL22857 | — | Ki | = | 1200.0 | nM | 5.92 |
| CHEMBL278762 | — | Ki | = | 4500.0 | nM | 5.35 |
| CHEMBL22777 | — | Ki | > | 1000.0 | nM | - |