Assay Detail
Binding
CHEMBL616107
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Compound was evaluated for its binding affinity with 5-hydroxytryptamine 1A receptor using membranes prepared from rat cerebral cortex
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Tissue | Cerebral cortex |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Orally active benzamide antipsychotic agents with affinity for dopamine D2, serotonin 5-HT1A, and adrenergic alpha1 receptors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 3 | 7.60 | 8.60 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL59878 | — | — | 1 | 8.60 |
| CHEMBL85 | RISPERIDONE | 4.0 | 1 | 6.60 |
| CHEMBL54 | HALOPERIDOL | 4.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL59878 | — | Ki | = | 2.5 | nM | 8.60 |
| CHEMBL85 | RISPERIDONE | Ki | = | 253.0 | nM | 6.60 |
| CHEMBL54 | HALOPERIDOL | Ki | > | 1000.0 | nM | - |