Assay Detail
Binding
CHEMBL616108
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Binding affinity towards rat 5-hydroxytryptamine 1A receptor using [3H]8-OH-DPAT radioligand.
54
Total Activities
54
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
Synthesis and structure-activity relationships of a new model of arylpiperazines. 1. 2-[[4-(o-methoxyphenyl)piperazin-1-yl]methyl]-1, 3-dioxoperhydroimidazo[1,5-alpha]pyridine: a selective 5-HT1A receptor agonist.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 54 | 7.38 | 9.22 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL8618 | NAN-190 | — | 1 | 9.22 |
| CHEMBL46918 | — | — | 1 | 8.62 |
| CHEMBL42706 | — | — | 1 | 8.42 |
| CHEMBL43992 | — | — | 1 | 8.39 |
| CHEMBL289873 | — | — | 1 | 8.36 |
| CHEMBL42810 | — | — | 1 | 8.26 |
| CHEMBL45253 | — | — | 1 | 8.24 |
| CHEMBL42644 | — | — | 1 | 8.14 |
| CHEMBL46881 | — | — | 1 | 8.06 |
| CHEMBL417709 | — | — | 1 | 8.00 |
| CHEMBL290039 | — | — | 1 | 7.95 |
| CHEMBL290203 | — | — | 1 | 7.72 |
| CHEMBL49 | BUSPIRONE | 4.0 | 1 | 7.69 |
| CHEMBL43332 | — | — | 1 | 7.61 |
| CHEMBL295168 | — | — | 1 | 7.50 |
| CHEMBL46471 | — | — | 1 | 7.46 |
| CHEMBL296713 | — | — | 1 | 7.34 |
| CHEMBL44786 | — | — | 1 | 7.27 |
| CHEMBL416984 | — | — | 1 | 7.25 |
| CHEMBL296413 | — | — | 1 | 7.24 |
| CHEMBL297844 | — | — | 1 | 7.24 |
| CHEMBL297887 | — | — | 1 | 7.23 |
| CHEMBL42396 | — | — | 1 | 7.18 |
| CHEMBL9666 | — | — | 1 | 7.17 |
| CHEMBL295244 | — | — | 1 | 7.11 |
| CHEMBL42404 | — | — | 1 | 7.11 |
| CHEMBL46470 | — | — | 1 | 7.07 |
| CHEMBL46885 | — | — | 1 | 7.05 |
| CHEMBL42654 | — | — | 1 | 7.00 |
| CHEMBL430567 | — | — | 1 | 6.92 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL8618 | NAN-190 | Ki | = | 0.6 | nM | 9.22 |
| CHEMBL46918 | — | Ki | = | 2.4 | nM | 8.62 |
| CHEMBL42706 | — | Ki | = | 3.8 | nM | 8.42 |
| CHEMBL43992 | — | Ki | = | 4.1 | nM | 8.39 |
| CHEMBL289873 | — | Ki | = | 4.4 | nM | 8.36 |
| CHEMBL42810 | — | Ki | = | 5.5 | nM | 8.26 |
| CHEMBL45253 | — | Ki | = | 5.7 | nM | 8.24 |
| CHEMBL42644 | — | Ki | = | 7.2 | nM | 8.14 |
| CHEMBL46881 | — | Ki | = | 8.8 | nM | 8.06 |
| CHEMBL417709 | — | Ki | = | 9.9 | nM | 8.00 |
| CHEMBL290039 | — | Ki | = | 11.3 | nM | 7.95 |
| CHEMBL290203 | — | Ki | = | 19.2 | nM | 7.72 |
| CHEMBL49 | BUSPIRONE | Ki | = | 20.5 | nM | 7.69 |
| CHEMBL43332 | — | Ki | = | 24.8 | nM | 7.61 |
| CHEMBL295168 | — | Ki | = | 31.7 | nM | 7.50 |
| CHEMBL46471 | — | Ki | = | 34.9 | nM | 7.46 |
| CHEMBL296713 | — | Ki | = | 45.5 | nM | 7.34 |
| CHEMBL44786 | — | Ki | = | 53.6 | nM | 7.27 |
| CHEMBL416984 | — | Ki | = | 55.9 | nM | 7.25 |
| CHEMBL296413 | — | Ki | = | 57.9 | nM | 7.24 |
| CHEMBL297844 | — | Ki | = | 57.7 | nM | 7.24 |
| CHEMBL297887 | — | Ki | = | 58.4 | nM | 7.23 |
| CHEMBL42396 | — | Ki | = | 65.8 | nM | 7.18 |
| CHEMBL9666 | — | Ki | = | 68.0 | nM | 7.17 |
| CHEMBL42404 | — | Ki | = | 78.5 | nM | 7.11 |
| CHEMBL295244 | — | Ki | = | 78.6 | nM | 7.11 |
| CHEMBL46470 | — | Ki | = | 85.3 | nM | 7.07 |
| CHEMBL46885 | — | Ki | = | 89.9 | nM | 7.05 |
| CHEMBL42654 | — | Ki | = | 101.0 | nM | 7.00 |
| CHEMBL430567 | — | Ki | = | 120.0 | nM | 6.92 |
| CHEMBL47200 | — | Ki | = | 123.0 | nM | 6.91 |
| CHEMBL46525 | — | Ki | = | 128.0 | nM | 6.89 |
| CHEMBL478 | CHLOROPHENYLPIPERAZINE | Ki | = | 130.0 | nM | 6.89 |
| CHEMBL41978 | — | Ki | = | 154.0 | nM | 6.81 |
| CHEMBL274866 | — | Ki | = | 175.0 | nM | 6.76 |
| CHEMBL46535 | — | Ki | = | 234.0 | nM | 6.63 |
| CHEMBL9434 | PHENYLPIPERAZINE | Ki | = | 380.0 | nM | 6.42 |
| CHEMBL46802 | — | Ki | = | 418.0 | nM | 6.38 |
| CHEMBL46672 | — | Ki | = | 444.0 | nM | 6.35 |
| CHEMBL42881 | — | Ki | = | 500.0 | nM | 6.30 |
| CHEMBL45007 | — | Ki | = | 598.0 | nM | 6.22 |
| CHEMBL295527 | — | Ki | > | 1000.0 | nM | - |
| CHEMBL296724 | — | Ki | > | 1000.0 | nM | - |
| CHEMBL298286 | — | Ki | > | 10000.0 | nM | - |
| CHEMBL46377 | — | Ki | > | 10000.0 | nM | - |
| CHEMBL47040 | — | Ki | > | 1000.0 | nM | - |
| CHEMBL432495 | — | Ki | > | 10000.0 | nM | - |
| CHEMBL44876 | — | Ki | > | 1000.0 | nM | - |
| CHEMBL291165 | — | Ki | > | 1000.0 | nM | - |
| CHEMBL289784 | — | Ki | > | 10000.0 | nM | - |