Assay Detail
Binding
CHEMBL616109
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In vitro ability to displace [3H]8-hydroxy-2-(di-n-propylamino) tetralin binding from 5-hydroxytryptamine 1A receptor site in rat brain hippocampus
22
Total Activities
22
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Tissue | Hippocampus |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
Structure-activity relationship studies of central nervous system agents. 5. Effect of the hydrocarbon chain on the affinity of 4-substituted 1-(3-chlorophenyl)piperazines for 5-HT1A receptor site.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 22 | 6.69 | 8.57 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL279906 | — | — | 1 | 8.57 |
| CHEMBL8412 | IPSAPIRONE | 2.0 | 1 | 8.47 |
| CHEMBL27378 | — | — | 1 | 8.26 |
| CHEMBL26650 | — | — | 1 | 7.74 |
| CHEMBL284092 | GEPIRONE | 4.0 | 1 | 7.50 |
| CHEMBL27192 | — | — | 1 | 6.91 |
| CHEMBL281918 | — | — | 1 | 6.90 |
| CHEMBL478 | CHLOROPHENYLPIPERAZINE | 2.0 | 1 | 6.84 |
| CHEMBL26737 | — | — | 1 | 6.82 |
| CHEMBL307204 | — | — | 1 | 6.80 |
| CHEMBL27298 | — | — | 1 | 6.78 |
| CHEMBL26540 | — | — | 1 | 6.70 |
| CHEMBL413527 | — | — | 1 | 6.66 |
| CHEMBL76783 | — | — | 1 | 6.60 |
| CHEMBL78740 | — | — | 1 | 5.14 |
| CHEMBL282367 | — | — | 1 | 4.83 |
| CHEMBL26782 | — | — | 1 | 4.51 |
| CHEMBL284887 | — | — | 1 | 4.31 |
| CHEMBL26904 | — | — | 1 | - |
| CHEMBL418386 | — | — | 1 | - |
| CHEMBL27099 | — | — | 1 | - |
| CHEMBL77181 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL279906 | — | Ki | = | 2.67 | nM | 8.57 |
| CHEMBL8412 | IPSAPIRONE | Ki | = | 3.4 | nM | 8.47 |
| CHEMBL27378 | — | Ki | = | 5.54 | nM | 8.26 |
| CHEMBL26650 | — | Ki | = | 18.4 | nM | 7.74 |
| CHEMBL284092 | GEPIRONE | Ki | = | 31.8 | nM | 7.50 |
| CHEMBL27192 | — | Ki | = | 122.0 | nM | 6.91 |
| CHEMBL281918 | — | Ki | = | 127.0 | nM | 6.90 |
| CHEMBL478 | CHLOROPHENYLPIPERAZINE | Ki | = | 143.0 | nM | 6.84 |
| CHEMBL26737 | — | Ki | = | 152.0 | nM | 6.82 |
| CHEMBL307204 | — | Ki | = | 159.0 | nM | 6.80 |
| CHEMBL27298 | — | Ki | = | 166.0 | nM | 6.78 |
| CHEMBL26540 | — | Ki | = | 202.0 | nM | 6.70 |
| CHEMBL413527 | — | Ki | = | 220.0 | nM | 6.66 |
| CHEMBL76783 | — | Ki | = | 251.0 | nM | 6.60 |
| CHEMBL78740 | — | Ki | = | 7220.0 | nM | 5.14 |
| CHEMBL282367 | — | Ki | = | 14800.0 | nM | 4.83 |
| CHEMBL26782 | — | Ki | = | 30800.0 | nM | 4.51 |
| CHEMBL284887 | — | Ki | = | 49000.0 | nM | 4.31 |
| CHEMBL26904 | — | Ki | > | 100000.0 | nM | - |
| CHEMBL418386 | — | Ki | > | 100000.0 | nM | - |
| CHEMBL27099 | — | Ki | > | 100000.0 | nM | - |
| CHEMBL77181 | — | Ki | > | 100000.0 | nM | - |