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Assay Detail

CHEMBL616119

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
In vitro inhibition of [3H]- 8-OH-DPAT binding to cloned cell line containing human 5-hydroxytryptamine 1A receptor by Panlabs assay
2
Total Activities
2
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Confidence 8 — Homologous single protein target
Curated By Autocuration

Target

5-hydroxytryptamine receptor 1A (CHEMBL214)
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

Development of fluorine-18-labeled 5-HT1A antagonists.
Lang L, Jagoda E, Schmall B, Vuong BK, Adams HR, Nelson DL, Carson RE, Eckelman WC.
J Med Chem (1999) 42 : 1576 -1586
PubMed 10229627 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
Ki 2 9.36 9.61

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL38413 1 9.61
CHEMBL43297 1 9.10

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL38413 Ki = 0.247 nM 9.61
CHEMBL43297 Ki = 0.791 nM 9.10