Assay Detail
Binding
CHEMBL616120
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement of specific [3H]- 5-HT binding to cloned human 5-hydroxytryptamine 1A receptor stably expressed in HeLa cells
11
Total Activities
11
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | HeLa |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Parallel synthesis of 3-aryloxy-2-propanolamines and evaluation as dual affinity 5-HT(1A) and 5-HT re-uptake ligands.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 11 | 8.35 | 9.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL327126 | — | — | 1 | 9.00 |
| CHEMBL326751 | — | — | 1 | 8.96 |
| CHEMBL111065 | — | — | 1 | 8.77 |
| CHEMBL114452 | — | — | 1 | 8.66 |
| CHEMBL111713 | — | — | 1 | 8.64 |
| CHEMBL111021 | — | — | 1 | 8.55 |
| CHEMBL112841 | — | — | 1 | 8.26 |
| CHEMBL323441 | — | — | 1 | 8.22 |
| CHEMBL114453 | — | — | 1 | 8.08 |
| CHEMBL500 | PINDOLOL | 4.0 | 1 | 7.62 |
| CHEMBL113326 | — | — | 1 | 7.14 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL327126 | — | Ki | = | 1.0 | nM | 9.00 |
| CHEMBL326751 | — | Ki | = | 1.1 | nM | 8.96 |
| CHEMBL111065 | — | Ki | = | 1.7 | nM | 8.77 |
| CHEMBL114452 | — | Ki | = | 2.2 | nM | 8.66 |
| CHEMBL111713 | — | Ki | = | 2.3 | nM | 8.64 |
| CHEMBL111021 | — | Ki | = | 2.8 | nM | 8.55 |
| CHEMBL112841 | — | Ki | = | 5.5 | nM | 8.26 |
| CHEMBL323441 | — | Ki | = | 6.0 | nM | 8.22 |
| CHEMBL114453 | — | Ki | = | 8.3 | nM | 8.08 |
| CHEMBL500 | PINDOLOL | Ki | = | 24.0 | nM | 7.62 |
| CHEMBL113326 | — | Ki | = | 72.0 | nM | 7.14 |