Assay Detail
Binding
CHEMBL616121
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Evaluated for the binding constant at [3H]8-OH-DPAT-labeled human 5-hydroxytryptamine 1A receptor
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Effect of ring fluorination on the pharmacology of hallucinogenic tryptamines.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 6 | 7.34 | 8.77 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL342986 | — | — | 1 | 8.77 |
| CHEMBL142936 | DIETHYLTRYPTAMINE | — | 1 | 7.33 |
| CHEMBL143202 | — | — | 1 | 7.31 |
| CHEMBL337590 | — | — | 1 | 7.07 |
| CHEMBL143031 | — | — | 1 | 6.94 |
| CHEMBL444612 | — | — | 1 | 6.59 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL342986 | — | Ki | = | 1.7 | nM | 8.77 |
| CHEMBL142936 | DIETHYLTRYPTAMINE | Ki | = | 47.0 | nM | 7.33 |
| CHEMBL143202 | — | Ki | = | 49.0 | nM | 7.31 |
| CHEMBL337590 | — | Ki | = | 84.5 | nM | 7.07 |
| CHEMBL143031 | — | Ki | = | 114.0 | nM | 6.94 |
| CHEMBL444612 | — | Ki | = | 256.0 | nM | 6.59 |