Assay Detail
Binding
CHEMBL616126
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In vitro binding affinity towards Human 5-hydroxytryptamine 1A receptor by the displacement of [3H]8-OH-DPAT
10
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
Studies toward the discovery of the next generation of antidepressants. Part 2: incorporating a 5-HT(1A) antagonist component into a class of serotonin reuptake inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 10 | 7.29 | 7.96 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL104229 | — | — | 1 | 7.96 |
| CHEMBL322915 | — | — | 1 | 7.71 |
| CHEMBL421027 | — | — | 1 | 7.67 |
| CHEMBL318738 | — | — | 1 | 7.36 |
| CHEMBL442391 | — | — | 1 | 7.14 |
| CHEMBL104144 | — | — | 1 | 7.11 |
| CHEMBL105390 | — | — | 1 | 7.08 |
| CHEMBL105204 | — | — | 1 | 7.08 |
| CHEMBL318604 | — | — | 1 | 7.03 |
| CHEMBL106481 | — | — | 1 | 6.77 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL104229 | — | Ki | = | 10.9 | nM | 7.96 |
| CHEMBL322915 | — | Ki | = | 19.6 | nM | 7.71 |
| CHEMBL421027 | — | Ki | = | 21.6 | nM | 7.67 |
| CHEMBL318738 | — | Ki | = | 43.9 | nM | 7.36 |
| CHEMBL442391 | — | Ki | = | 71.6 | nM | 7.14 |
| CHEMBL104144 | — | Ki | = | 78.3 | nM | 7.11 |
| CHEMBL105390 | — | Ki | = | 83.3 | nM | 7.08 |
| CHEMBL105204 | — | Ki | = | 83.6 | nM | 7.08 |
| CHEMBL318604 | — | Ki | = | 92.6 | nM | 7.03 |
| CHEMBL106481 | — | Ki | = | 168.2 | nM | 6.77 |